These findings confirm previous works on the mode of action of gliclazide and suggest that the drug has a specific "in vitro" effect on blood platelets. It interferes with platelet synthetic activity which maintains platelet glycogen storage and reduces the level of heavy populations with high ...
Class of drugsMode of actionHbAlc (%) reductionFPG reductionPPG reductionCost Sulfonylureas Insulin secretagogue 0.8–2.0 Moderate to marked Moderate Low cost Meglitinides Insulin secretagogue 0.5–2.0 Mild Moderate to marked Cost effective GLP-1RA Insulin secretagogue 0.5 —1.0 Moderate to marked ...
These findings confirm previous works on the mode of action of gliclazide and suggest that the drug has a specific “in vitro” effect on blood platelets. It interferes with platelet synthetic activity which maintains platelet glycogen storage and reduces the level of heavy populations with high ...
The mode of action and clinical pharmacology of gliclazide: a review. Diabetes Res. Clin. Pract. 14, S21–36 (1991). Article PubMed Google Scholar Al-Omary, F. A. M. Gliclazide. In Profiles of Drug Substances, Excipients and Related Methodology, Elsevier, 125–191 (2017). Renier, G...
Serum parameters, enzyme markers, hepatic oxidative stress markers, gene and protein expression studies and histopathological analyses were performed in rat liver to identify the mode of action of the combination drug administration. Results The in vitro studies on HepG2 cells suggest a positive ...