Gliclazide has a long and stable action time, and is generally used in elderly patients. Gliclazide is generally absorbed quickly after oral administration, reaching a peak in 3-4 hours, and 80% is excreted from the kidneys. If the kidney function is not good, attention should be paid. ...
Gliclazide 说明书
Mechanism of action is to stimulate pancreatic β cells to release insulin, and then the high blood sugar drops. This may be because that sulfonylurea combines with β cell surface receptor, and increases the activation and simultaneously improves the sensitivity of outer periphery of the target ...
In all three tissues, the action of the drug on whole-cell KATP currents was rapidly reversible. In inside-out patches on beta-cells, gliclazide (1 micromol/l) produced a maximum of 66 +/- 13 % inhibition (n = 5), compared with more than 98 % block in the whole-cell configuration...
Ionic liquids (IL) technology provides a useful platform to achieve the topical delivery of therapeutic agents, because of its capability to improve skin permeability. While the majority of the researches aimed to achieve local action by topical IL delivery, systemic action of therapeutic agents by ...
The objective of this research was to formulate fast dissolving tablet of gliclazide for rapid action. Direct compression method was adapted to prepare the fast dissolving tablets. All formulations are evaluated for post-compression parameters like hardness, disintegration time, weight variation, ...
This prolongation of the residence time of the drug in the body, from optimized SGNCs formulation, indicates the delayed steady state delivery of gliclazide from PLGA nanocrystal for better therapeutic efficacy in T2DM management. Additionally, the pharmacokinetic-pharmacodynamic correlation of pure ...
The body mass index, fasting plasma glucose, immunoreactive insulin, homeostasis model assessment of insulin resistance, hemoglobin A 1c (HbA 1c), total cholesterol, triglycerides, high-density lipoprotein cholesterol, prothrombin time, activated partial thromboplastin time, fibrinogen, thrombin-antithrombin...
The objective of this research was to formulate fast dissolving tablet of gliclazide for rapid action. Direct compression method was adapted to prepare the fast dissolving tablets. All formulations are evaluated for post-compression parameters like hardness, disintegration time, weight variation, ...