Mechanism of action is to stimulate pancreatic β cells to release insulin, and then the high blood sugar drops. This may be because that sulfonylurea combines with β cell surface receptor, and increases the activation and simultaneously improves the sensitivity of outer periphery of the target ...
Influence of the semisynthetic bile acid (MKC) on the ileal permeation of gliclazide in healthy and diabetic rats. Al-Salami H, Butt G, Tucker I, Mikov M. ... The action of gliclazide, a sulphonylurea with beneficial extrapancreatic effects in diabetes, may be enhanced by administering prob...
Mechanism of action is to stimulate pancreatic β cells to release insulin, and then the high blood sugar drops. This may be because that sulfonylurea combines with β cell surface receptor, and increases the activation and simultaneously improves the sensitivity of outer periphery of the target ...
The influence of synthetic derivative of bile acids on hypoglycemic effect of gliclazide The aim of this work was to study the effect of 3伪,7伪 -dihydroxy-12-oxo-5脽 cholanate (MKC), an oxo derivative of cholic acid, on the hypoglycemic action... Ra拧kovi膰 Aleksandar,Mikov Momir 被引...
Tokumura, T., Muraoka, A., Machida, Y.: Improvement of oral bioavailability of flurbiprofen from flurbiprofen/β-cyclodextrin inclusion complex by action of cinnarizine. Eur. J. Pharm. Biopharm. 73, 202–204 (2009) Article CAS Google Scholar Khan, M.Z., Rausl, D., Zanoski, R., Zida...
In addition to this, the use of stabilizer either ionic or non-ionic along with the PLGA is essential to attain physical stability of SGNCs formulation, with the mechanism of action of electrostatic repulsion and steric stabilization35,36. The nonionic surfactants and polymers that are commonly ...
The influence of synthetic derivative of bile acids on hypoglycemic effect of gliclazide The aim of this work was to study the effect of 3伪,7伪 -dihydroxy-12-oxo-5脽 cholanate (MKC), an oxo derivative of cholic acid, on the hypoglycemic action... Ra拧kovi膰 Aleksandar,Mikov Momir 被引...
affecting the onset of action and intensity of pharmacological effects in vivo [2,3]. A second-generation sulfonylureas, Gliclazide (GCZ), [1-(3-azabicyclo (3, 3,0) oct-3-yl)-3-(p-tolylsulfonyl) urea] has transformed the treatment of type 2 diabetes/noninsulin dependent diabetes mellitus...