Mechanism of action is to stimulate pancreatic β cells to release insulin, and then the high blood sugar drops. This may be because that sulfonylurea combines with β cell surface receptor, and increases the activation and simultaneously improves the sensitivity of outer periphery of the target ...
Mechanism of action is to stimulate pancreatic β cells to release insulin, and then the high blood sugar drops. This may be because that sulfonylurea combines with β cell surface receptor, and increases the activation and simultaneously improves the sensitivity of outer periphery of the target ...
BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF MICRONIZED GLICLAZIDE IN HUMAN PLASMA BY LC-MS/MS AND ITS PHARMACOKINETIC STUDIES Drugs having poor oral bioavailability, fail to reach the minimum effective concentration required to achieve pharmacological action. Improvement of the or... R Bose,S Dan...
Drugs having poor oral bioavailability, fail to reach the minimum effective concentration required to achieve pharmacological action. Improvement of the oral bioavailability of the drug is the most realistic approach, as it is the most preferred and convenient route of administration. Besides numerous ...
The influence of synthetic derivative of bile acids on hypoglycemic effect of gliclazide The aim of this work was to study the effect of 3伪,7伪 -dihydroxy-12-oxo-5脽 cholanate (MKC), an oxo derivative of cholic acid, on the hypoglycemic action... Ra拧kovi膰 Aleksandar,Mikov Momir 被引...
In addition to this, the use of stabilizer either ionic or non-ionic along with the PLGA is essential to attain physical stability of SGNCs formulation, with the mechanism of action of electrostatic repulsion and steric stabilization35,36. The nonionic surfactants and polymers that are commonly ...
Sulfonylureas such as gliclazide were reported to enhance insulin signalling and have a direct action on skeletal muscle glucose disposal through a GLUT4-mediated effect [47,48,49,50]. Gliclazide is usually used as a substitute for metformin-intolerant type 2 diabetic patients [51,52,53]. ...
As per the Biopharmaceutics Classification System (BCS), the dissolution of drugs belonging to Class II (low solubility and high permeability) is considered the rate-limiting phase, affecting the onset of action and intensity of pharmacological effects in vivo [2,3]. A second-generation ...