Blasco I, Humpel C and Grubeck‑Loebenstein B: Glial cells: astrocytes and oligodendrocytes during normal brain aging. In: Handbook of the Neuroscience of Aging. Hof PR and Mobbs CV (eds). Else
Groh et al. show that a maladaptive white matter-associated microglia state that emerges in aging recruits peripheral T cells to the CNS, which leads to degeneration of myelinated axons and loss of function. Jonathan K. Monteiro Veronique E. Miron ...
Metabolic diseases, such as obesity and type 2 diabetes, can disrupt the brain-to-periphery communication mediated by glial cells, highlighting the relevance of these cell types in the pathophysiology of such complications. An improved understanding of how glial cells integrate and respond to ...
43]. Recentin vivostudies have suggested that radial glia form the majority ofprogenitor cellsthat give rise to neurons of the cortical germinal zone and might also function as a self-renewing multipotent population[44–46]. Moreover, it has recently been hypothesized that adult SVZ cells might...
Exercise training restores the endothelial progenitor cells number and function in hypertension: implications for angiogenesis. J Hypertens. 2012;30:2133–43. https://doi.org/10.1097/HJH.0b013e3283588d46. Article CAS PubMed Google Scholar Kamarova M, Baig S, Patel H, Monks K, Wasay M, ...
Competition among adult brain cells has not been extensively researched. To investigate whether healthy glia can outcompete diseased human glia in the adult forebrain, we engrafted wild-type (WT) human glial progenitor cells (hGPCs) produced from human e
We analyzed TTR expression in the peripheral nerve of the FAP mouse model using real-time polymerase chain reaction (qPCR) analysis and determined the subcellular localization of TTR in satellite cells from mice dorsal root ganglia (DRG) and Schwann cells (SC). SC from patients and control subje...
An emerging picture suggests that glial cells’ loss of beneficial roles or gain of toxic functions can contribute to neurodegenerative conditions. Among glial cells, microglia and astrocytes have been shown to play phagocytic roles by engulfing synapses
A failure to meet this demand for iron can result in persistent neurological and cognitive dysfunction. On the other hand, increased iron levels and iron accumulations in specific brain regions and cells are hallmarks for numerous neurodegenerative diseases, but also for the aging brain [1,2,3,...
Glial cells – traditionally thought as simply the “glue” of the nervous system – are increasingly recognized to play a critical role in the development and function of the brain. Importantly, glial cell dysfunction has recently been shown to contribute to various neurological disorders, such as...