Although knowledge of the development and differentiation of glial cells has significantly increased in recent years, there are still many questions unanswered. The first section of the book is devoted to this very active topic and includes contributions on Schwann cells, oligodendrocytes, astroglia and microglia.B Castellano LópezProgress in Brain...
Glial cells that express NG2 and platelet-derived growth factor receptor α are found throughout the mature CNS. These cells are mitotically active, but their functions remain enigmatic. A genetic fate-mapping study in this issue shows that these abundan
Glial cells make up theotherbrain cells. They are a diverse group of cells that are versatile in their range of functions. Glial cells were first discovered in 1838 by Robert Remak. He discovered Schwann cells (named after Theodor Schwann, who confirmed Remak’s discovery), which are a type...
In addition, glia have only one type of process connected to the cell body, and unlike full-fledged neurons, they retain the ability to divide. This is necessary given their function as support cells, which subjects them to more wear and tear than nerve cells and does not require them to ...
Groh et al. show that a maladaptive white matter-associated microglia state that emerges in aging recruits peripheral T cells to the CNS, which leads to degeneration of myelinated axons and loss of function. Jonathan K. Monteiro Veronique E. Miron ...
explanation of the function of glial cells, given that their functions include myelination of the CNS, contribution to the blood–brain barrier, removal, recycling and storage of transmitter substances, control of the concentration of potassium ions in the perineuronal milieu and storage of glycogen....
4.3.1Microglia, and glial cells In the brain and spinal cord,glial cells, includingmicrogliaand astrocytes, play a critical role in regulating immune function. In the peripheralnervous system(DRGs,trigeminal ganglia, and sympathetic and parasympathetic ganglia)satellite glial cells(SGC) play a critical...
enteric glial cellsgut-brain axisNew investigations have shown that 'activated' enteric glial cells (EGCs), astrocyte-like cells of the enteric nervous system (ENS), represent a possible extra-CNS trigger point of the neurodegenerative processes in impaired intestinal permeability conditions. The early...
precursor cellsintermediate filamentsnestinGFAPvimentinGlial fibrillary acidic protein (GFAP) is an intermediate filament protein considered to be the best astroglial marker. However, the predominant cell population in adult human brain tissue cultures does not express GFAP; these cells have been termed "...
Glial Development Neural Progenitors Neuronal Cell Fate and Cell Lineage Introduction The mammalian cerebral cortex, controlling the highest brain functions, contains billions of neurons and glia. During mouse cortical development, radial glial cells (RGCs), known as primary neural stem cells (NSCs), ...