O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine to serine and threonine residues. This review emphasizes its role in regulating the signaling pathways of pyroptosis. Specifically, the O-GlcNAcylation of GSDMD is linked to the modulation of ...
the set ofO-GlcNAcylated proteins in humans, known as theO-GlcNAcylome, consists of 8000 proteins and continues to grow (TheO-GlcNAc Database, v1.3) [17]. This review provides an
In this review, we have highlighted the important roles ofO-GlcNAcylation on core histones and its cross talk with the other nucleosomal PTMs. It is very likely that knownO-GlcNAcylated proteins represent only a fraction of the broader role it plays in epigenetics. By developing more refined m...
O-GlcNAcylation emerges as a pivotal regulator of brain development and function, positioning it as an attractive therapeutic target for CNS disorders. This review has delineated the physiological and pathological roles of O-GlcNAcylation, elucidated the molecular mechanisms underpinning these functions, and...
O-GlcNAcylation emerges as a pivotal regulator of brain development and function, positioning it as an attractive therapeutic target for CNS disorders. This review has delineated the physiological and pathological roles of O-GlcNAcylation, elucidated the molecular mechanisms underpinning these functions, and...
In this review, we discuss the beneficial role and potential mechanisms by which O-GlcNAcylation promotes self-tolerance and maintains cellular homeostasis under stress conditions, with a focus on the cardiovascular and central nervous systems (CNS)....
two related enzymes, OGT and OGA, show high expression and activity in the brain24,25. These findings strengthen the emerging notion that O-GlcNAcylation plays an important role in various neural functions. Therefore, in this review, we will focus on the importance of O-GlcNAcylation in neural...
In this review, we summarize recent findings on the role of O-GlcNAcylation in immunity to create a perspective on its relevance in the TME. Ultimately, we propose that O-GlcNAcylation is largely restricting tumor control, and thus may also serve as a target to improve antitumor immunity. ...
In this review, we describe the potential role of O-GlcNAcylation in ovarian cancer through the regulation of cellular signaling pathways, including p53, RhoA/ROCK/MLC, ERM, and β-catenin pathways. Moreover, we also discuss the O-GlcNAcylation of several proteins in ovarian cancer, such as ...
Review Article Published: 10 May 2017 Protein O-GlcNAcylation: emerging mechanisms and functionsXiaoyong Yang & Kevin Qian Nature Reviews Molecular Cell Biology volume 18, pages 452–465 (2017)Cite this article 30k Accesses 840 Citations 43 Altmetric Metrics details This article has been updated...