We found that glucose strongly stimulates O-linked N-acetylglucosaminylation (O-GlcNAcylation) on YY1. Glycosylated YY1 no longer binds the retinoblastoma protein (Rb). Upon dissociation from Rb, the glycosylated YY1 is free to bind DNA. The ability of the O-glycosylation on YY1 to disrupt ...
摘要: Discusses the regulation of YY1, a zinc finger DNA-binding transcription factor, by O-linked N-acetylglucosaminylation. Importance of YY1 in the development of mammalian embryos; Pathway of glucose metabolism; Cell cycle transition.年份: 2003 ...
The carbohydrate addition known asO-linked N-acetylglucosaminylation (O-GlcNAc modification or O-GlcNAcylation) has been observed lately in several proteins with nuclear localization (17). O-GlcNAc is formed by the enzymatic addition of N-acetylglucosamine (GlcNAc) to serine and threonine residues ...
Cancer Cell Metabolism Gene Expression O-GlcNAc O-GlcNAcylation O-GlcNAcase Introduction O-Linked β-N-acetylglucosaminylation (O-GlcNAcylation),2 i.e. the attachment of N-acetylglucosamine (GlcNAc) to serine and threonine residues via a β-O-linkage, is a novel post-translational modification of...
O-GlcNAcylation is an O-linked β-N-acetyl-glucosamine (O-GlcNAc)-monosaccharide modification of serine or threonine in proteins that plays a vital role in many critical cellular processes. Owing to its low molecular weight, uncharged property, and difficulty in distinguishing from β-N-acetyl-ga...
O-GlcNAc glycosylation (O-GlcNAcylation) corresponds to the addition of N-acetylglucosamine on serine and threonine residues of cytosolic and nuclear prote... T. Issad a b,E. Masson a b,P. Pagesy a b - 《Diabetes & Metabolism》
In this study, using the established cells for inducibly expressing hSCP1 proteins, we monitored the modification of β-O-linked N-acetylglucosamine (O-GlcNAc). O-GlcNAcylation is one of the most common post-translational modifications (PTMs). To gain insight into the PTM of hSCP1, we used ...
Mechanistically, loss of TRAP1-O-GlcNAcylation decreased TRAP1 binding to ATP, and interaction with its client protein succinate dehydrogenase (SDHB). Taken together, TRAP1-O-GlcNAcylation serves to regulate mitochondrial metabolism by the reversible attenuation of TRAP1 chaperone activity. 展开 ...
Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease Regulation of the amyloid precursor protein (APP) processing by ±- and -secretases is of special interest to Alzheimer's disease (AD), as these proteases ... T Jean-...
Therefore, the neuroprotective chitosan-based FTY720 nanoformulation, PP2A (Protein phosphatase 2) activator has been employed to evaluate the PP2A role in the O-GlcNacylation of synuclein in an in vivo PD model. The neuroprotective effect of our nanoformulation is attributed to the upregulation of ...