O-GlcNAcylation is an O-linked β-N-acetyl-glucosamine (O-GlcNAc)-monosaccharide modification of serine or threonine in proteins that plays a vital role in many critical cellular processes. Owing to its low molecular weight, uncharged property, and difficulty in distinguishing from β-N-acetyl-ga...
In this study, using the established cells for inducibly expressing hSCP1 proteins, we monitored the modification of β-O-linked N-acetylglucosamine (O-GlcNAc). O-GlcNAcylation is one of the most common post-translational modifications (PTMs). To gain insight into the PTM of hSCP1, we used ...
We found that glucose strongly stimulates O-linked N-acetylglucosaminylation (O-GlcNAcylation) on YY1. Glycosylated YY1 no longer binds the retinoblastoma protein (Rb). Upon dissociation from Rb, the glycosylated YY1 is free to bind DNA. The ability of the O-glycosylation on YY1 to disrupt ...
Protein O-GlcNAcylation-a novel cell survival signal in cardiac stem cells the 尾-O-linkage of N-acetylglucosamine ( i.e. , O-GlcNAc) to proteins is a unique post-translational modification that confers cardioprotection from var... A Zafir,Q Li,R Bolli,... - The FASEB Journal 被引量: ...
Using an in vitro approach, we found that O -GlcNAcylation reduces the phase separation propensity of the EWS N -terminal low complexity region (LCR N ) under different conditions, including in the presence of the arginine-and glycine-rich RNA-binding domains (RBD). O -GlcNAcylation enhances ...
Mechanistically, loss of TRAP1-O-GlcNAcylation decreased TRAP1 binding to ATP, and interaction with its client protein succinate dehydrogenase (SDHB). Taken together, TRAP1-O-GlcNAcylation serves to regulate mitochondrial metabolism by the reversible attenuation of TRAP1 chaperone activity. 展开 ...
O-GlcNAcylation is a post-translational modification of proteins that controls a variety of cellular processes, is chronically elevated in diabetes mellitus, and may contribute to the progression of diabetic complications, including diabetic nephropathy. Our previous work showed that increases in the O-...
O-GlcNAcylation: the sweet side of the cancer. tumorigenesisO-GlcNAcylation is an O-linked 尾-N-acetylglucosamine (O-GlcNAc) moiety linked to the serine or threonine residues in proteins. O-GlcNAcylation... de,Queiroz,Rafaela,... - 《Frontiers in Oncology》 被引量: 58发表: 2014年 Regulation...
O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP) The amyloid-β precursor protein (APP) was shown to be O-GlcNAcylated 15 years ago, but the effect of this modification on APP processing and formation of ... KT Jacobsen,K Iverfeldt - 《Biochem...
Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease Regulation of the amyloid precursor protein (APP) processing by ±- and -secretases is of special interest to Alzheimer's disease (AD), as these proteases ... T Jean-...