此外,研究还揭示了 O-GlcNAcylation 修饰在神经元和胶质细胞中的动态变化,以及其与神经元结构和功能相关蛋白的修饰改变。这些结果为深入理解 O-GlcNAcylation 修饰在 ALS 发病机制中的作用提供了重要依据,也为开发新的 ALS 治疗方法奠定了基础。不过,研究也指出,O-GlcNAcylation 修饰与磷酸化之间的相互作用在 ALS 发病...
他们发现,O - GlcNAcylation(一种蛋白质翻译后修饰)相关的自噬 - 溶酶体途径(Autophagy - Lysosome Pathway,ALP)在调节细胞分裂周期 27(Cell Division Cycle 27,CDC27)蛋白稳定性方面发挥着重要作用,并且抑制 O - GlcNAcylation 和 BTZ 联合治疗可能是治疗 MM 的潜在策略,这一发现为 MM 的治疗开辟了新的道路。
Protein O-GlcNAcylation: emerging mechanisms and functions. Nat. Rev. Mol. Cell Biol. 18, 452–465 (2017). Article CAS PubMed PubMed Central Google Scholar Gorelik, A. et al. Genetic recoding to dissect the roles of site-specific protein O-GIcNAcylation. Nat. Struct. Mol. Biol. 26,...
通过检查进食时间、HBP途径多种代谢物水平以及O-GlcNAcylation水平之间的关系,发现进食会驱动UDP-GlcNAc水平增加,同时伴随修饰水平增加。此外,还发现在非正常时间进食会导致O-GlcNAcylation节律减弱,而在正常时间进食会增强节律,说明除了饮食之外还有可能有生物...
Maintenance of O-GlcNAc homeostasis is essential for optimal cellular function, and disruption of the cellular O-GlcNAcylation 'buffer' may contribute to the pathogenesis of various human diseases. O-GlcNAcylation can be viewed as the essential 'grease and glue' of the cell: it acts as a '...
大家好,本周给大家分享一篇JACS上的文章“Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells”,本文通讯作者来自北京国家蛋白质科学中心的秦伟捷教授和浙江大学生命科学学院的易文教授。前者的主要研究方向为新材料和新试...
The HBP pathway and Protein O-GlcNAcylation. GFPT1/2, GNPNAT1, PGM3, UAP1 in the HBP pathway generates UDP-GlcNAc. OGT can then O-GlcNAcylate protein substrates with UDP-GlcNAc as donor. O-GlcNAcylation has pleiotropic effects on substrates and can be removed by OGA ...
O-GlcNAcylation is a unique monosaccharide modification that is ubiquitously present in numerous nucleoplasmic and mitochondrial proteins. The hexosamine biosynthesis pathway (HBP), which is a key branch of glycolysis, provides the unique sugar donor UDP
必应词典为您提供o.glcnacylation的释义,网络释义: 糖基化修饰;单醣乙醯化;
This review discusses the potential role of O-GlcNAcylation in ovarian tumorigenesis, with a focus on its regulation of various cellular signaling pathways, including p53, RhoA/ROCK/MLC, Ezrin/Radixin/Moesin (ERM), and β-catenin. This review also emphasizes the O-GlcNAcylation of critical ...