G protein-coupled receptorGHSR1aGPCRdimerisationghrelinghrelin receptorThe growth hormone secretagogue receptor 1a (GHSR1a) is intriguing because of its potential as a therapeutic target and its diverse molecular interactions. Initial studies of the receptor focused on the potential therapeutic ability for...
进一步地,如后述实施例3所述,通过将对于特定细胞的标记物(例如,神经细胞前驱细胞的标记物巢蛋白或神经细胞的标记物Map2(Microtuble-associatedprotein2))与GHS-R进行双重染色,可以确认特定细胞中GHS-R是否表达,有助于了解作用于GHS-R的物质的作用。例如,巢蛋白阳性细胞也被抗GHS-R的抗体共染色。另外,在神经细胞中...
[D-Lys3]-GHRP-6_ghrelin受体(GHS-R1a)拮抗剂_Apexbio [D-Lys3]-GHRP-6
Stimu- lation by ghrelin of p42/p44 mitogen-activated protein kinase through the GHS-R1a receptor: role of G-proteins and β-arrestins. J Cell Physiol 213, 187-200.Camin˜ a JP, Lodeiro M, Ischenko O, Martini AC, Casanueva FF (2007) Stimulation by ghrelin of p42/p44 mitogen-...
Three years later this orphan G-protein coupled receptor was deorphanized by the discovery of the 28 amino acid octanoylated peptide ghrelin [3]. Presently, GHSR1a is the only known receptor for ghrelin, and is expressed in multiple tissues including pituitary gland, pancreas, brain and thymus...
Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 2004; 145: 4645–4652. Article CAS Google Scholar Jerlhag E, Egecioglu E, Dickson SL, Andersson M, Svensson L, Engel JA . Ghrelin ...
The expression of GHS-R1a was indicated by green fluorescent protein (GFP), and confirmed by Reverse Transcription Polymerase Chain Reaction (RT-PCR) and Western blot. Results Enzymatic digestion of pAdGHS-R1a yielded a large fragment (approximately 30 kb) and a small fragment (4.5 kb), ...
Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 2004; 145: 4645–4652. Article CAS Google Scholar Jerlhag E, Egecioglu E, Dickson SL, Andersson M, Svensson L, Engel JA . Ghrelin ...
The pharmacological properties of this peptide are mediated by the type 1a growth hormone secretagogue receptor (GHS-R1a), a G-protein-coupled receptor localised predominantly in the pituitary gland and hypothalamus. The discovery of new agents that either mimic or modulate the actions of ghrelin ...
GPCRHeterodimersGrowth hormone secretagogue receptor 1a (GHSR1a), a member of the G protein-coupled receptor (GPCR) family, is a functional receptor of ghrelin. The expression levels and activities of GHSR1a are affected by various factors. In past years, it has been found that the ghrelin-...