Magnetic resonance imaging (MRI) studies have revealed cortical and subcortical structural alterations in psychiatric and neurological disorders12,13,14, and the discovery of genetic contributions to brain structure variation has begun15,16. Recent imaging-genetics studies detected the first genetic loci ...
The structure of the brain is largely based on genetic factors, but the specific variants that account for this high heritability are mostly unknown. In my graduate work, I have used genome-wide association to seek and find common genetic variants, which account for some portion of the ...
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults Article Open access 22 September 2020 Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives Article Open access 14 October 2022 Abunda...
The largest ever study of the genetics of the brain—encompassing some 36,000 brain scans—has identified more than 4,000 genetic variants linked to brain structure. The results of the study, led by researchers at the University of Cambridge, are published inNature Genetics. Our brains are ver...
For each of 32,256 participants with post-quality-control MRI and genetic data (Methods), and each of 73 bilaterally paired regional measures of brain structure, we calculated hemispheric asymmetry indexes (AI) as (left − right)/((left + right)/2) (for 33 cortical surface area...
The hippocampus, with its complex subfields, is linked to numerous neuropsychiatric traits. While most research has focused on its global structure or a few specific subfields, a comprehensive analysis of hippocampal substructures and their genetic corre
Using data from the UK Biobank for participants primarily of European ancestry aged 38–73 years, including 94% white people, we identified a nonlinear association between sleep, with approximately 7h as the optimal sleep duration, and genetic and cognitive factors, brain structure, and mental ...
The basic uniformity in structure of the neocortex. The number of neuronal cell bodies has been counted in a narrow strip (30 micrometers) through the depth of the neocortex in several different functional a... ROCKEL A. J.,HIORNS R. W.,POWELL T. P. S. - 《Brain》 被引量: 1494发...
Twin studies offer the opportunity to determine the relative contribution of genes versus environment in traits of interest. Here, we investigate the extent to which variance in brain structure is reduced in monozygous twins with identical genetic make-up. We investigate whether using twins as compar...
the most prevalent glial cells in the brain. GM-BAG showed no enrichment in any of these cells. Our findings are consistent with understanding the molecular and biological characteristics of GM and WM. Oligodendrocytes are primarily responsible for forming the lipid-rich myelin structure, whereas ast...