The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental healthSleep duration, psychiatric disorders and dementias are closely interconnected in older adults. However, the underlying genetic mechanisms and brain structural changes are unknown....
so we also aim to investigate the combined effect of stratified polygenic-risk score (PRS) and lifestyle conferring risk for depression. To understand the neurobiological mechanisms by which genetic variation increases risk, the previous literature...
The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health 来自 Nature 喜欢 0 阅读量: 157 摘要: Sleep duration, psychiatric disorders and dementias are closely interconnected in older adults. However, the underlying genetic mechanisms...
The largest ever study of the genetics of the brain—encompassing some 36,000 brain scans—has identified more than 4,000 genetic variants linked to brain structure. The results of the study, led by researchers at the University of Cambridge, are published inNature Genetics. Our brains are ver...
when caused by mutations in genes that encode primary ciliary components27,28,29,30. This observation indicates that there are distinct and possibly organ-intrinsic mechanisms at play in brain development, but such mechanisms remain unidentified. Therefore the genetic origins of human brain asymmetry ...
The first cells to assume the neuroepithelial state lie over the notochord. Propagation of the neuroepithelial state (homoiogenetic induction) then proceeds via stretch-induced constriction of the apical microfilament rings, until ahemisphereis covered, at which point the high rate of change of the...
Women’s brain health is historically understudied, and little is therefore known about the mechanisms underlying epidemiological sex differences in neurodegenerative diseases, and how female-specific factors may influence women’s brain health across the lifespan. In this review, we summarize recent ...
Genetic mapping and evolutionary analysis of human-expanded cognitive networks Nat. Commun., 10 (2019), p. 4839 Google Scholar 69. S. Bianchi, et al. Dendritic morphology of pyramidal neurons in the chimpanzee neocortex: regional specializations and comparison to humans Cereb. Cortex, 23 (2013)...
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to...
The complex biological mechanisms underlying human brain aging remain incompletely understood. This study investigated the genetic architecture of three brain age gaps (BAG) derived from gray matter volume (GM-BAG), white matter microstructure (WM-BAG), and functional connectivity (FC-BAG). We identi...