Non-antibiotic antimicrobial (NAAM)TriclosanMutationWhole-genome sequencingAntibiotic resistance poses a major threat to public health. Overuse and misuse of antibiotics are generally recognized as the key factors contributing to antibiotic resistance. However, whether non-antibiotic, anti-microbial (NAAM) ...
The emergence of antibiotic resistance among important bacterial pathogens has generated the need to develop new and more effective therapies. All classes of antibiotics in use at present were identified using simple screens that identified compounds by their ability to inhibit bacterial growth. However,...
The World Health Organization has a goal of universal drug susceptibility testing for patients with tuberculosis. However, molecular diagnostics to date have focused largely on first-line drugs and predicting susceptibilities in a binary manner (classify
Molecular characteristics of class 1 and class 2 integrons and their relationships to antibiotic resistance in clinical isolates of Shigella sonnei and Shi... To analyse the gene cassettes and determine the roles of class 1 and class 2 integrons in antibiotic-resistant strains of Shigella sonnei (...
Transposons may carry with them additional genes, moving these genes from one location to another with them. For example, bacterial transposons can relocateantibiotic resistancegenes, moving them from chromosomes to plasmids. This mechanism has been shown to be responsible for the colocalization of mul...
In terms of transporters, we detected that the rs11568658 variant of the ABCC4 gene which accounts for 10.6% of the 1KVG, might have impacts on the function of the multidrug resistance-associated protein MRP4, thereby affecting the therapeutic response of remdesivir [35,36]. We also found ...
To stabilize proteins, the DDD system uses trimethoprim, a commonly used antibiotic that is much less expensive than Shld-1. Trimethoprim is anti-malarial drug that kills Plasmodium parasites. Therefore, use of the DDD system must be accompanied by the DHFR gene, which confers resistance to ...
Escherichia coli; cefotaxime; gentamicin; antibiotic resistance; extended-spectrum beta-lactamase; combination treatment; Transposon Directed Insertion-site Sequencing; helper drugs1. Introduction Drug-resistant infections account for the death of around 700,000 people globally every year, and this number ...
More than 500 unique cases of herbicide resistance have been discovered worldwide [1]. Many of these herbicide resistance cases are caused by genetic changes other than the target site and are therefore referred as non-targeted-site resistance (NTSR) cases [2]. Since many NTSR cases constitute...
2.7. Correlation between Antibiotic Resistance and ESBL Genes Two hundred and seventy-two isolates were phenotypically positive for ESBLs; 270 were confirmed by PCR to have ESBL-coding genes alone or in combination and two were negative. The most common gene combinations among clinical isolates were...