Oxidative DNA damage is important to the evolution of antibiotic resistance: Evidence of mutation bias and its medicinal implications Several studies have revealed that the reactive oxygen species (ROS) induced by antibacterial stimulation accelerates the evolution of antibiotic resistanc... ZY Wang,M ...
The microbiota can achieve resistance to antibiotics through four different mechanisms these are reduced membrane permeability for antibiotics, antibiotics inactivation, efflux of the antibiotic outside cell and mutation of gene encoding target of antibiotic. Additionally, extracellular sequestration of ...
Antibiotic-resistanceHere, we found that the photocatalysis (PC) could elicit bacterial stress response that transiently mediate some mechanism such as efflux pumps, biofilm formation, increased mutation rates (3-5-fold changes), leading to the improved antibiotic-tolerance. The time needed to ...
C. Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest. Nucleic Acids Res. 46, 3753–3763 (2018). Article CAS PubMed PubMed Central Google Scholar Mitcheltree, M. J., Stevenson, J. W., Pisipati, A. & Myers, A. G....
Several promising strategies based on combining or cycling different antibiotics have been proposed to increase efficacy and counteract resistance evolution, but we still lack a deep understanding of the physiological responses and genetic mechanisms that underlie antibiotic interactions and the clinical applic...
DNA mutationDNA processingDNA replicationmultiple drug resistancedoi:10.1128/9781555815615.ch18Virginia L. WatersJohn Wiley & Sons, LtdWaters V. The dissemination of antibiotic resistance by bacterial conjugation. In: Bonomo R, Tolmasky ME, editors. Enzyme-mediated rersistance to antibiotics Mechanisms,...
This chapter contains sections titled: Mechanism of Bacterial ResistanceMutationTransformation and TransductionConjugationMobile ElementsEffluxRibosomal Pr... MC Roberts - John Wiley & Sons, Inc. 被引量: 12发表: 2011年 Research advances in genetic mechanisms of bacterial antibiotic resistance Bacteria can ...
Furthermore, by widening the population bottleneck that occurs during antibiotic selection and promoting the establishment of a more diverse range of mutant lineages, PYO increases apparent rates of mutation to antibiotic resistance to a degree that can rival clinically relevant hypermutator strains. ...
In biofilm evolved populations, clones presenting a moderate MIC increase of up to 24 µg/mL of amikacin carried a loss of function mutation in the sbmA gene only, or mutations not previously linked to antibiotic resistance. By contrast, clones exhibiting the highest MIC (up to 128 ...
Fig. 1: Community interactions, as well as resistance genotype, affect the response to antibiotic exposure. Full size image Ecological context can influence the selection for antimicrobial resistance Fig. 2: Fitness and selection consequences of differential effects of antibiotic concentration on growth ...