The continuous emergence of new MRSA isolates with no effective treatment options underscores a real threat to health among humans and animals, and the number of effective antibiotic therapies decreases with each passing year. In this review, we provide an overview of the most comm...
Resistance mechanisms to circumvent the toxic action of antimicrobials have been identified and described for all known antimicrobials currently available for clinical use in human and veterinary medicine. Acquired bacterial antibiotic resistance can result from the mutation of normal cellular genes, the ...
The successful candidate will work on a fully funded project investigating the evolutionary genetics of multidrug resistance in bacteria, aiming to gain a better understanding of distributions of fitness effects of resistance mutations and their epistatic interactions, as well as the repeatability and ...
CARD,综合的抗生素耐药性数据库 (Comprehensive Antibiotic Resistance Database)。 在单个基因组的组装过程中,组装程序使用全基因组一致测序覆盖率 (Uniform sequencing coverage across the genome)来纠正测序错误并识别重复序列和质粒 (一些组装程序利用质粒的较高覆盖率来区分被分离基因组中的染色体和质粒序列)。 但WMS...
The emergence of antibiotic resistance among important bacterial pathogens has generated the need to develop new and more effective therapies. All classes of antibiotics in use at present were identified using simple screens that identified compounds by their ability to inhibit bacterial growth. However,...
Since the introduction of methicillin, methicillin resistant S. aureus (MRSA) was appeared in 1961 in England. MRSA produces specific penicillin-binding pr... T Ito,K Hiramatsu - 《Nihon Rinsho Japanese Journal of Clinical Medicine》 被引量: 1发表: 1997年 Genetics of antibiotic resistance in me...
In recent years the emergence and spread of antibiotic resistance in Neisseria gonorrhoeae has increased markedly. Chromosomal resistance to penicillin and tetracycline is due to the effects of one or more mutations and is generally low-level. However, the effects of these mutations are additive. Thu...
Their ability to produce antibiotic by cosynthesis was tested by placing a strip of agar cut from the combin... V Delic,J Pigac,G Sermonti - 《J Gen Microbiol》 被引量: 45发表: 1969年 Chloramphenicol resistance in Streptomyces coelicolor A3(2): Possible involvement of a transposable ...
By acquiring or evolving resistance to one antibiotic, bacteria can become cross-resistant to a second antibiotic, which further limits therapeutic choices. In the opposite scenario, initial resistance leads to collateral sensitivity to a second antibiotic, which can inform cycling or combinatorial ...
DNA transformation, PCR-based restriction analysis, and DNA sequencing collectively showed that the metronidazole resistance of this strain was due to mutation in rdxA (gene HP0954 in the full genome sequence of H. pylori 26695) and that resistance did not depend on mutation in any of the ...