INCIDENCE OF GENETIC MARKERS ASSOCIATED WITH MULTIPLE MYELOMA CHARACTERIZED BY FISHAlonso-Muoz, CarlosNaranjo-Mendoza, MiltonCortes-Penagos, CarlosJournal of the Association of Genetic Technologists
Murine models for multiple myeloma (MM) are often used to investigate pathobiology of multiple myeloma and disease progression. Unlike transgenic mice models, where it is known which oncogene is driving MM disease, the somatic aberrations of spontaneous syngeneic 5T models of MM have not yet been ...
Blue line represents the threshold of genome-wide significance after correction for multiple testing (q-value = 0.05) Full size image Table 2 Genome- and chromosome-wide significant associations between SNP markers and zoometrics-related traits in dromedary camels Full size table PVRIG, STAG3,...
To detect cytokine production and activation markers of CAR T cells, a 5:1 E: T ratio was used, and culture supernatant and cells were collected 24 h post co-culture. ELISA Cytokines (TNF-α, IFN-γ and IL-2) released by CAR T cells were measured in duplicate using specific ELISA kit...
34 For most cases, the fraction of malignant cells in the pathologic specimen was greater than 80%, as determined by cell suspension cytofluorimetric or tissue section immunohistochemical analysis of cell surface markers and by Ig gene rearrangement analysis.34 For most samples, a mononuclear cell ...
The mean channel fluorescent intensity of the plasma cell peaks for each of these markers was 12.7, 17.4 and 35.3 respectively demonstrating the superiority of CD38-biotin + streptavidin FITC. Analysis after propidium iodide staining provided a good correlation with the slide technique (r = 0.71; ...
Chemical-genetic interaction profiling in model organisms has proven powerful in providing insights into compound mechanism of action and gene function. However, identifying chemical-genetic interactions in mammalian systems has been limited to low-throu
For each selected PGS, linkage disequilibrium (LD) pruning was performed via the LDlink's SNPclip tool (Machiela and Chanock, 2015) using the non-Finnish Europeans of the 1000 Genomes Project retaining only one SNP for markers in high LD (r2 > 0.8). Additionally, only SNPs with a minor...
This strong genetic component provides an opportunity to determine the pathophysiological processes in AD and to identify new biological features, new prognostic/diagnostic markers and new therapeutic targets through translational genomics. Characterizing the genetic risk factors in AD is therefore a major ...
The frequent occurrence of BCL-6 rearrangement in DLLC characterized by extranodal involvement represents one of the few genetic markers for this subset of lymphoma (8). Rearrangements of BCL-1, BCL-2, or BCL-3 have been documented infrequently in extranodal lymphomas (36-38), while 5 of 12...