Tumor cells from six patients with immunoglobulin G (IgG) multiple myeloma were analyzed for surface antigens, cytoplasmic paraprotein, morphology, and response to various culture conditions. The tumor marker was the paraprotein idiotype. Low numbers of tumor cells were found in the blood of most ...
GPRC5D is an atypical Class C orphan G protein-coupled receptor. Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for therapeutic interventions, including monoclonal antibodies, CAR-T cells, and T-cell eng
Objective Beta‐2‐microglobulin is a serum marker of tumor burden in multiple myeloma (MM). Our aim was to correlate serum β‐microglobulin levels in patients with MM to tumor burden determined by low‐dose whole‐body CT (LDWBCT). Materials and Methods A total of 52 patients with newly ...
Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have used in vivo murine models of MM to show significant induc
The idiotype (Id) determinant on the multiple myeloma (MM) protein can be regarded as a tumor-specific marker. Immunotherapy directed at the MM Id may stem... VL Reichardt,CY Okada,A Liso,... - 《Blood》 被引量: 1148发表: 1999年 Complete molecular remissions induced by patient-specific ...
DNA Topoisomerase IIα in Multiple Myeloma: A Marker of Cell Proliferation and Not Drug Resistance R, Butch AW, McCourty A, Kelly K, Brynes RK (2001) DNA topoisomerase II in multiple myeloma: a marker of cell proliferation and not drug resistance... CS Wilson,LJ Medeiros,R Lai,... - ...
The approach is based on quantitative studies of M component synthesis by human myeloma cells in vitro and in vivo. These measurements of the tumor's marker protein are then used as a means to calculate the total body burden of tumor cells in this disorder. The technique provides the basis ...
Multiple myeloma is an incurable plasma cell malignancy that is mostly restricted to the bone marrow. Cancer-induced dysfunction of cytotoxic T cells at the tumor site may be responsible for immune evasion and therapeutical failure of immunotherapies. Therefore, enhanced knowledge about the actual stat...
Multiple myeloma is an incurable plasma cell malignancy that is mostly restricted to the bone marrow. Cancer-induced dysfunction of cytotoxic T cells at the tumor site may be responsible for immune evasion and therapeutical failure of immunotherapies. Therefore, enhanced knowledge about the actual stat...
The interaction between multiple myeloma (MM) cells and the bone marrow stroma constitutes the basis of myeloma pathogenesis and has led the way for the corresponding therapeutic strategies. The aim of this study is to evaluate tumor-associated macrophages (TAMs) which is an important element of ...