An acute phase response is typically associated with myeloma [5,57]. Interleukin -6 (IL-6) has a significant role in B cell differentiation; especially in the final differentiation of B cells to mature plasma cells. A number of studies have indicated that targeting the IL-6 pathway inhibits ...
A significant increase has been reported in reticuloendothelial neoplasms in patients with inflammatory bowel diseases. We present two rare cases of multiple myeloma in patients with inflammatory bowel diseases. One was in a 58-year-old woman with ulcerative colitis, and the other was in a 59-...
The Significance of Inflammatory Markers in the Prognosis of Newly Diagnosed Multiple Myeloma Patients 来自 钛学术 喜欢 0 阅读量: 131 作者:B Chen,G Lin,J Shi,W Zhang,F Wang 摘要: Objective: To explore the significance of the ratio of neutrophils to lymphocytes (NLR), monocytes to lymphocytes...
Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have usedin vivomurine models of MM to show significant induction of nerve growth factor (NGF) by the tumour...
Additionally, several other cytokines and surface markers that are typically absent in healthy donor bone marrow were identified, he says. Among the inflammatory markers, IL-6 was notably upregulated, which was expected; however, investigators also found an increase in IL-10, which is known for ...
Multiple myeloma (MM) is an incurable haematological malignancy, caused by the uncontrolled proliferation of plasma cells within the bone marrow (BM). Obesity is a known risk factor for MM, however, few studies have investigated the potential of dietary
Multiple myeloma is an incurable plasma cell malignancy that is mostly restricted to the bone marrow. Cancer-induced dysfunction of cytotoxic T cells at the tumor site may be responsible for immune evasion and therapeutical failure of immunotherapies. Th
C-reactive protein(CRP):A high level of this inflammatory marker may indicate a poor prognosis. Lactate dehydrogenase (LDH):A high level of this normal enzyme indicates extensive myeloma. In cases of IgM disease or WM, a serum viscosity test may be performed. ...
Multiple myeloma is ablood cancerthat occurs when white blood cells, calledplasmacells, increase out of control in the bones. Myeloma destroys the bone by making osteoclasts – cells that break down old bones – become more active and weaken your bones. At the same time, myeloma cells slow ...
pesticides, certain chemicals, and asbestos108and also in those with a history ofinflammatory disease109or allergies.110High levels of human herpes virus-8 (HHV-8) virus have been reported inbone marrow stromal cellsof myeloma patients, indicating a possibleviral etiologyfor thediseasein sel...