The Significance of Inflammatory Markers in the Prognosis of Newly Diagnosed Multiple Myeloma PatientsObjective: To explore the significance of the ratio of neutrophils to lymphocytes (NLR), monocytes to lymphocytes (MLR), and platelets to lymphocytes (PLR) in the prognosis of patients with newly ...
How Does Multiple Myeloma Affect Your Bones? Multiple myeloma is a blood cancer that occurs when white blood cells, called plasma cells, increase out of control in the bones. Myeloma destroys the bone by making osteoclasts – cells that break down old bones – become more active and weaken yo...
Abnormal tumor microenvironment and immune escape in multiple myeloma (MM) are associated with regulatory T cells (Tregs), which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells.
tumor heterogeneity, tumor microenvironment, therapeutic resistance in MM, which offers a profound opportunity to improve the diagnosis and identify biomarkers for precision medicine of MM. SCS: single-cell sequencing; MM: multiple myeloma; MGUS: monoclonal...
Patient-related factors include older age, recent surgery or immobiliza- tion, and decreased functional status; the major disease-related factor is increased pro-thrombotic status from heightened inflammatory markers, especially at diagnosis. There is a high level of factor VIII and von Willebrand ...
Immunomodulatory imide drugs (IMiDs) heralded the shift in tide towards immune approaches which saw the repurposing of thalidomide as the first-generation IMiD for myeloma, with second- and third-generation analogues lenalidomide and pomalidomide becoming staples in Myeloma regimens [2], [3], [4]....
Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have used in vivo murine models of MM to show significant induction of nerve growth factor (NGF) by the tum...
Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of plasma cells. Although therapeutic advances have been made to improve clinical outcomes and to prolong patients’ survival in the past two decades, MM remains la
Multiple myeloma (MM) is an incurable haematological malignancy, caused by the uncontrolled proliferation of plasma cells within the bone marrow (BM). Obesity is a known risk factor for MM, however, few studies have investigated the potential of dietary
Fig. 1. Risk factors for bleeding and thrombosis in multiple myeloma patients. Abbreviations: LAC, lupus anticoagulant; APCR, activated protein C resistance; PAI-1, plasminogen activator inhibitor; FVIII factor VIII, FX: factor X, VWF: von Willenbrand factor; TAFI, thrombin activatable fibrinolysis...