Example of familial risk stratification for CAD. CAD, coronary artery disease; PVD, peripheral vascular disease; Early onset CAD, less than age 55 in men and less than age 65 in women. Full size image Pedigree analysis can also reveal characteristic patterns of disease suggestive of a genetic ...
Credit: Pixabay/CC0 Public Domain A large team of researchers affiliated with a host of institutions across Japan has identified multiple loci associated with ancestry-specific risk factors for coronary artery disease. In their paper published in the journalNature Genetics, the group describes their a...
Novel genetic markers for chronic kidney disease in a geographically isolated population of Indigenous Australians: Individual and multiple phenotype genome-wide association study Vignesh Arunachalam, Rodney Lea, Wendy Hoy, Simon Lee, Susan Mott, Judith Savige, John D. Mathews, Brendan J. ...
Coronary artery disease (CAD) is the leading killer of people with type 2 diabetes, and it's not a secret killer. Physicians can assess the risks of major coronary events for someone withdiabetesfor reasonably well. Among those with diabetes, there are well-established indicators of risk such ...
The invention provides a method for predicting responsiveness to statin treatment for reducing coronary heart disease (CHD) risk in a human, the method com... D Shiffman,J Devlin 被引量: 0发表: 2021年 Associations of genetic markers of the sympathoadrenal system and endothelial dysfunction with...
et al. Predictive accuracy of a polygenic risk score-enhanced prediction model vs a clinical risk score for coronary artery disease. JAMA 323, 636–645 (2020). PubMed PubMed Central Google Scholar Khera, A. V. et al. Genome-wide polygenic scores for common diseases identify individuals ...
Background: Patients suffering from inflammatory bowel disease (IBD) are at an increased risk for coronary artery disease (CAD). Despite the evident coincidence of these inflammatory conditions, a causal role of IBD for CAD has never been proven. Recently, many single nucleotide polymorphisms (SNPs...
Background Observational studies have indicated that depression is associated with coronary artery disease (CAD) and myocardial infarction. Nevertheless, causal associations between depression and cardiovascular diseases remain controversial. Hence, we conducted a Mendelian randomization and mediation analysis to...
et al. Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers. Nat. Genet. 47, 1272–1281 (2015). Article CAS PubMed PubMed Central Google Scholar Gudbjartsson, D. F. et al. Large-scale whole-genome sequencing of ...
forest plots for HCM and DCM analyses are presented in Supplementary Figs.8and9. Discussion Our large-scale analyses of spQRSTa and fQRSTa -- two emerging markers for arrhythmogenesis and cardiovascular disease -- significantly advance our understanding of their basic biology and relationships with...