CAD, coronary artery diseaseCXCL1, chemokine (C-X-C motif) ligand 1GWAS, genome-wide association studyLDLR, low-density lipoprotein receptorLPL, lipoprotein lipaseMI, myocardial infarctionPCSK9, proprotein convertase subtilisin/kexin type 9cardiovascular diseasescoronary artery disease...
Coronary artery disease (CAD) is a common disease caused by the interactions between genetic background and environments. Genetic determinant is one of the most important risk factors. By far, more than 160 susceptibility loci and several disease-causing genes have been identified through genome-wide...
Genome editing to introduce mutations that are protective against coronary artery disease into the population could prove curative with a one-time injection, although substantial additional work is needed to confirm efficacy and safety, and to address the underlying ethics.Abstract...
Genome-wide association studies (GWAS) have identified over two hundred chromosomal loci that modulate risk of coronary artery disease (CAD). The genes affected by variants at these loci are largely unknown and an untapped resource to improve our understanding of CAD pathophysiology and identify poten...
Genome editing to introduce mutations that are protective against coronary artery disease into the population could prove curative with a one-time injection, although substantial additional work is needed to confirm efficacy and safety, and to address the underlying ethics. Abstract Coronary artery diseas...
Coronary artery disease (CAD) and myocardial infarction (MI) are the leading causes of death in industrialized countries [4]. Genome-wide association studies have identified more than 160 variants, mainly located in the non-coding genome, that are associated with CAD/MI [13]. In an exome-wid...
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The Genetic Basis of Coronary Artery Disease: From Candidate Genes to Whole Genome Analysis MassimoFranchini, ...Pier MannuccioMannucci, inTrends in Cardiovascular Medicine, 2008 Coronary artery diseaseis a major socioeconomic problem in industrialized as well as in developing countries. Thus, many ...
Coronary artery disease (CAD) is the leading killer of people with type 2 diabetes, and it's not a secret killer. Physicians can assess the risks of major coronary events for someone withdiabetesfor reasonably well. Among those with diabetes, there are well-established indicators of risk such...
In: The Metabolic Basis of Inherited Disease.(6th eds.) Scriver ER, Beaudet AL, Sly WS, Valle D eds. 1989: l2l5-50. Graw-Hill Book Co., New York.10) Khoo KI, van Acker P, Deslypere JP, et al. Clin Genet 2000; 58: 98-105.11) Pownall HJ, Gotto AM Jr. In: Structure and...