www.nature.com/npjsba ARTICLE OPEN IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells Minami Ando1, Shigeyuki Magi 1, Masahide Seki2, Yutaka Suzuk
Expression of cytokine and apoptotic genes : a role for NF-kB in the regulation of TNF- related apoptosis inducing ligand (TRAIL) expressionTudor Baetu
18,19,20,21. Inhibiting NF-κB, either globally by ablating one copy of the p65 gene or conditionally by removing IKKβ alleles in skeletal muscle fibers or myeloid cells, improved dystrophic pathology18. Cell or gene therapy designed to target p65 or IKK, respectively, were also...
Antigen-specific receptors on T lymphocytes are generated by the rearrangement of germline DNA to produce immunoglobulinhke receptor molecules. Unlike the immunoglobulin receptors on B cells, however, T cells do not secrete antigen-specific molecules but
(Fig.1G). Second, to unbiasedly identify co-regulated gene programs, we transposed the meta-cell matrix and clustered genes based on response similarity upon perturbation. We identified 5 distinct gene programs (Fig.1H). The heatmap visualizations reveal relationships between perturbation modules and...
Previous studies revealed that IL6, IL8, XIAP, and cIAP were modulated by NF-κB RelA/p65 as target genes (46., 47., 48., 49., 50.). We demonstrated that TIP60 is involved in NF-κB pathway through activating the transcriptional activity of RelA/p65 in response to TNF-α stimulation...
The TT genotype results in higher levels of mRNA in response to lipopolysaccharide stimulation, and the authors suggested that this could prevent a strong inflammatory reaction. Curiously enough, BD patients have higher ATG5 mRNA levels compared to healthy controls [39]. This study, however, did ...
The binding of TNF to TNF-R1 initiates downstream signaling that culminates in the activation of NF-kB and c-Jun, two major transcription factors [35, 36]. The NF-kappa B pathway is divided into two different but interacting pathways: the classical NF-kappa B essential modulator (NEMO)—a...
Interestingly, GSEA revealed that PD-L1 and PD-L2 expression correlated genes were enriched to the hallmark gene sets TNFα signaling via Nuclear factor kappa B (NFKB) (genes regulated by NF-kB in response to TNF), Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling (genes up-...
The enrichment of genes in specific signaling pathways suggests the involvement of immune and inflammatory processes in the response to EE, while the mitochondrial dysfunction provides insights into the potential impact on cellular energy metabolism and barrier function. Modules of WGCNA...