The impact of efferocytosis-related genes (ERGs) on the diagnosis of colorectal cancer (CRC) remains unclear. In this study, efferocytosis-associated biomarkers for the diagnosis of CRC were identified by integrating data from transcriptome sequencing an
Expression of cytokine and apoptotic genes : a role for NF-kB in the regulation of TNF- related apoptosis inducing ligand (TRAIL) expressionTudor Baetu
The innate immunity acts during the early phases of infection and its failure in response to a multilayer network of co-infections is cause of immune system dysregulation. Epidemiological SARS-CoV-2 infections data, show that Influenza Virus (FLU-A-B-C) and Respiratory Syncytial Virus (RSV) are...
The TT genotype results in higher levels of mRNA in response to lipopolysaccharide stimulation, and the authors suggested that this could prevent a strong inflammatory reaction. Curiously enough, BD patients have higher ATG5 mRNA levels compared to healthy controls [39]. This study, however, did ...
Target genes of ultraviolet stress response in cutaneous melanocytes, potentially associated with solar-induced melanocarcinogenesis, were characterized by cDNA microarray technology. In cultured normal human melanocytes, 198 genes out of ≈9000 arrayed were found modulated ≥ 1.9 times following artificial ...
Interestingly, this CTRA response was mitigated in patients with HPV-related HNC and may explain the lower level of fatigue they experience relative to HPV-unrelated HNC. Fatigue, one of the most frequently reported and distressing cancer symptoms (Janaki et al., 2010), is prognostic for poor ...
Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However, whether IFN-γ negatively regulates components of the LPS response, and how this may affect macrophage activation, is st...
The cAMP response element binding protein (CREB) also drives thrombospondin-1 transcription, and is involved in the formation and maintenance of arterial thrombosis25,26. Wang et al. showed that the TF Yin Yang (YY)1 up-regulated vitronectin expression by binding to the rs2227721-G (rs is ...
Macrophages are also major contributors to the formation of a complete vasculature. TAMs are mainly regulated by nuclear factor-kappaB (NF-kB) pathway through the cancer-related inflammation. NF-kB promotes tumor progression by the upregulation of proangiogenic factors and tumor-promoting cytokines such...
Differentially expressed genes (up- and down-regulated subsets) from the three AMP-AD studies were used to construct custom gene sets and used in a similar way as the c2.cp (a superset of c2.cp.biocarta, c2.cp.kegg, and c2.cp.reactome plus a few other data sources) (v7.0) subsets ...