Since several chemotherapy agents act like TNF to both promote apoptosis and activate NF-B, understanding the role of NF-B in suppressing apoptosis may have significant clinical applications. To understand the effects of stimulation with TNF and the role of NF-B in regulating this response, a ...
The impact of efferocytosis-related genes (ERGs) on the diagnosis of colorectal cancer (CRC) remains unclear. In this study, efferocytosis-associated biomarkers for the diagnosis of CRC were identified by integrating data from transcriptome sequencing an
In the medical management of patients affected by COVID-19, some valuable therapeutic strategies imply the use of AIDs, especially those non-steroidal AIDs (NSAIDs), to mitigate the ongoing excessive inflammatory response occurring after the early phases of the disease [22]. Indeed, several observ...
The cAMP response element binding protein (CREB) also drives thrombospondin-1 transcription, and is involved in the formation and maintenance of arterial thrombosis25,26. Wang et al. showed that the TF Yin Yang (YY)1 up-regulated vitronectin expression by binding to the rs2227721-G (rs is ...
Interestingly, this CTRA response was mitigated in patients with HPV-related HNC and may explain the lower level of fatigue they experience relative to HPV-unrelated HNC. Fatigue, one of the most frequently reported and distressing cancer symptoms (Janaki et al., 2010), is prognostic for poor ...
Differentially expressed genes (up- and down-regulated subsets) from the three AMP-AD studies were used to construct custom gene sets and used in a similar way as the c2.cp (a superset of c2.cp.biocarta, c2.cp.kegg, and c2.cp.reactome plus a few other data sources) (v7.0) subsets ...
PPARs, especially PPARG, contribute to the inhibition of key pro-inflammatory genes such as NF-kB, TNFα, TGFβ, and the interleukins IL-1a and IL-6 [41, 42]. In a very recent study of CD14+ monocytes from systemic lupus erythematosus patients, it was reported that there was an ...
Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However, whether IFN-γ negatively regulates components of the LPS response, and how this may affect macrophage activation, is st...
Alzheimer’s disease (AD) is the most prevalent dementia disorder globally, and there are still no effective interventions for slowing or stopping the underlying pathogenic mechanisms. There is strong evidence implicating neural oxidative stress (OS) and
Whole-disc response to hypertonicity was studied in an ex vivo organ culture model, using wild-type and haploinsufficient TonEBP mice. Pro-inflammatory targets were induced by hypertonicity in discs from wild-type but not TonEBP-haploinsufficient mice. Mechanistically, NF-κB activity increased with...