Topics in Nucleic Acid Structure : Topics in Molecular and Structural Biology; volume 1 edited by S. Neidle General editors: W. Fuller and S. Neidle MacMil... D Shugar - 《Febs Letters》 被引量: 0发表: 1982年 A standard reference frame for the description of nucleic acid base-pair ...
Here we explore a general strategy for the rational design of nucleic acid catalysts that can be allosterically activated by specific nucleic-acid binding proteins. To demonstrate this we have combined a catalytic DNAzyme sequence and the consensus sequence recognized by specific transcription factors to...
How do animals get amino acids? What dictates the primary structure of a nucleic acid? How many amino acids exist in the human body? What are proteins in biology? Explore our homework questions and answers library Search Browse Browse by subject...
Increasing NA size led to an increased proportion of Lx in a hexagonal structure phase as in the case of T4 phage virus DNA. These observations were made using two Lx made from different lipids exhibiting negative and positive charged surface. We also demonstrated structural similarities between ...
The β-propeller and thigh domains in αV and the βI and hybrid domains in β8 are resolved in the structure (Fig. 2a, b). The co-crystallized peptide fragment of the TGF-β1 prodomain binds to the interface between the αV β-propeller and β8 βI domain. αVβ8 electron ...
3.Structure of viruses Most viruses are too small to be seen under light microscope. All viruses consists of an RNA or DNA core genome surrounded by a protein coat capsid. The combined viral genome and capsid is called the nucleocapsid. The nucleic acid of a virus is surrounded by a ...
Oseltamivir Tamiflu® (Roche) Sialic acid analog Neuraminidase inhibitor Influenza A and B Ribavirin Virazole® (Schering-Plough) Nucleoside analog Possibly no direct viral target HCV RSV C: Primarily active against Hepadnaviruses (HBV) Generic Name (Abbreviation) Trade NameStructureMechanism Viral Ta...
3b) is similar to the known structure of a transcription initiation complex21. We identified CedA adopting a ladle-like shape and binding the RNAP at the tip of a β-pincer formed by a lineage-specific sequence insertion βi4, β-lobe and σ70 (Fig. 3b–e)....
Structure and mechanism in complex general acid-base catalyzed reactions The mechanisms of acid and base catalyzed carbonyl and acyl group reactions are determined largely by the lifetime of the initial addition intermeidate. Catalysis through diffusion-controlled trapping by relatively strong acids or ...
This motif contains a standard homeodomain, called POUH, preceded by a conserved 75 to 82 amino acid sequence called POUS. This latter region is composed of four α-helices; the second and third form a classic HTH structure with the third helix lying in the major groove (Fig. 13-1, ...