the homoeologs have the potential to alter a gene’s expression and change its dosage relative to other homoeologs (Fig.1a). While previous genetic mapping studies in allopolyploid wheat identified several genes where regulatory variants associated with adaptive and domestication traits21,22,23,24als...
little is known about the involvement of these enzymes/genes in the disease from results obtained from studying patients in Caucasian population. Genetic variations of SIRT genes may affect the transcription regulation of the gene, or the translation and/or enzymatic ...
First, we always have tags that are mapped to ambiguous positions, and they may belong to multiple loci (such as gene families and splicing variants) in the genome sequence, especially when the length of SAGE tags is as short as 14 bp. There were 4,014 (20%) such tags in our case,...
respectively, separated by LoxPsym sites. Different promoter and terminator parts have different strengths (color scale). Upon induction of Cre recombination, blocks in each GEM are shuffled, resulting in a pool of GEM variants that differently influence expression of the gene...
Changes in m6A-modifying enzyme levels affect the expression of downstream oncogenes or tumor suppressor genes by altering mRNA methylation [16]. Furthermore, epigenetic markers potentially serve as diagnostic, prognostic, and predictive biomarkers and might be used as novel targets for cancer precision...
The gene–gene interaction (epitasis) is a point of major interest in elucidating how multiple common risk variants lead to the development of a complex disease such as SSc. We have previously investigated the putative epistasis between IRF5, STAT4 and BANK1. However, we failed to detect a ...
How does proteogenomics contribute to understanding cancer-specific protein variations? What types of genomic alterations are identified through the Protein Gene Expression Nexus (PEN) data set? How does the presence of cancer-specific variations affect protein coverage in cancer cells? How has the in...
Mutations in the CF gene affecting CFTR expression, protein levels or function, now known as CFTR variants, affect multiple organ systems including the lung, pancreas, liver, gut and reproductive organs. Changes in chloride and bicarbonate transportation across this channel impairs epithelial cell ...
Examples of static and dynamic eQTLs reflect how the detected local and distant regulatory variants affect the etrait gene expression under WW or WS conditions.aCombined Manhattan plot for different static, local eQTLs detected for individual etraits; demonstrating local genetic variants are significantly...
over tenfold increases, with most expression changes falling between one-third and three times (Fig.4b,d). Furthermore, SVs that affect gene expression were enriched within 3 kb flanking regions of genes. These results indicate the important role of SVs in fine-tuning gene expression levels....