Polynucleotides and polypeptides were Transcription Factors incorporated into Plant Expression Vectors and expressed ectopically. It has been demonstrated that transgenic plants transformed with many of these Expression Vectors are more resistant to Disease and, in some cases, more than one type of pathoge...
The authors used these new insights to systematically test which of these protein-encoding genes affected a large range of diseases. They discovered more than 1,800 examples in which more than one disease was driven by variations in an individual gene and its protein products. What emerged was ...
Gene expression involves transcription, translation and the turnover of mRNAs and proteins. The degree to which protein abundances scale with mRNA levels and the implications in cases where this dependency breaks down remain an intensely debated topic. Here we review recent mRNA–protein correlation st...
Nanostructures built from biomolecules such as proteins, DNA and RNA are attracting attention in many areas of biological and materials sciences. Such nanoscale engineering was pioneered with proteins, yet the use of DNA is rapidly gaining traction. What are the advantages of the different biopolymers...
aegypti, sperm and seminal fluid, respectively. Differential gene expression of accessory glands from virgin and mated males suggests that transcripts encoding proteins involved in protein translation are upregulated post-mating. Several SFP transcripts were also modulated after mating, but >90% remained...
Trunk-disease fungi Peptide fragmentation analysis de novo peptide sequencing Bioinformatics Gene ontology 1. Introduction Current work in fungal proteomics and bioinformatics of phytopathogenic filamentous fungi is in a very early stage. There are an estimated 1.5–5 million species of fungi thought to...
Some proteins linked with ALS bind and colocalize with L1 ORF1p ribonucleoprotein particles in cytoplasmic RNA granules. Increased expression of several ALS-associated proteins, including TAR DNA Binding Protein (TDP-43), strongly limits cell culture retrotransposition, while some disease-related ...
More recent studies suggest an additional role of the mitochondrion in ionic homeostasis, apoptosis, and aging (8, 9, 10, 11, 12, 13). Consequently, many diseases have been attributed to mitochondrial defects, including Alzheimer’s disease, Parkinson’s disease, Friedreich ataxia, diabetes ...
Growing evidence suggests that the FGF–Klotho endocrine system also has a crucial role in the pathophysiology of ageing-related disorders, including diabetes, cancer, arteriosclerosis and chronic kidney disease. Therefore, targeting the FGF–Klotho endocrine axes might have therapeutic benefit in multiple...
Wool fibre diameter (WFD) is one of the wool traits with higher economic impact. However, the main genes specifically regulating WFD remain unidentified. In this current work we have used Agilent Sheep Gene Expression Microarray and proteomic technology to investigate the gene expression patterns of...