A hybrid promoter, mac, was constructed by incorporating part of mas promoter and enhancer region of CaMV35S promoter. It enhanced the GUS expression by 3 to 5 times when compared with the GUS expression under the control of CaMV35S promoter with double enhancer in the leaves and 10 to 15...
The cloned ap2 gene enhancer and promoter base composition is entirely consistent with the ap2 gene sequences in GenBank, dna recombinant technology the gene enhancer and promoter restructuring in pegfp-n1 eukaryotic expression vector was successfully constructed adipose tissue-specific expression p ...
Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial transcriptional specificity in metazoans. Since the discovery of the first enhancer element in simian virus 40, there has been substantial interest in unraveling ...
Enhancers in focus: insights into spatiotemporal gene expression control This review summarizes the current understanding of enhancer-promoter interactions (EPIs), a key feature of genome structure, in gene regulation and disease. EPIs are crucial for proper gene activity, and their alteration by ...
Transcription factors bind to specific DNA sequences called enhancer and promoter/silence sequences to recruit RNA polymerase to an appropriate transcription site and signal which part of the gene will be transcribed. The promoters and enhancers or silencers are located within regulatory regions of the...
Gene complex contains promoter, enhancer, signal peptide, coding sequence and an intron 来自 Google Patents 喜欢 0 阅读量: 18 公开/公告号: US5304489 A 公开/公告日期: Apr 19, 1994 发明人: JM Rosen 被引量: 422 摘要: Described is a method of targeting specific genes to the mammary gland ...
In general, each gene could be associated with one promoter and multiple enhancers. Figure 1. Illustration of gene regulation: (A) transcription factor (TF)-gene regulation through proximal promoter regions; (B) TF-gene regulation through distal enhancer regions; (C) a gene regulatory network (...
“super-enhancers” (SEs): long stretches of sequences with gene regulatory activity that generally drive greater levels of gene expression than regular enhancers [69,70,71,72]. We will return to Mediator and BRD4 later in the review to discuss their possible roles in enhancer–promoter ...
Promoter/enhancer cassettes for keratinocyte gene therapy (letter) 1999 The Society for Investigative Dermatology, Inc D Sawamura,X Meng,S Ina,... - 《Journal of Investigative Dermatology》 被引量: 0发表: 1999年 131 Promoter/enhancer cassettes for keratinocyte gene therapy: Control of transgene ...
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis Snyder and colleagues show global loss of promoter–enhancer connectivity during early colorectal carcinogenesis and the dependency of gene dysregulation during this process on the base...