Enhancers play a crucial role in gene regulation but the participation of enhancer transcripts (i.e. enhancer RNA, eRNAs) in regulatory systems remains unclear. We provide a computational analysis on eRNAs using genome-wide data across 12 mouse tissues. The expression of genes targeted by transcrib...
GENE enhancersThe article focuses on a study conducted by Samstein and colleagues which shows that differentiation of regulatory T (TReg) cells does not involve changes in the accessibility of enhancers targeted by the transcriptional regulator FOXP3....
(1983) . Enhancer elements in immunoglobulin genes . NatureEnhancer Elements in Immunoglobulin Genes , Michael A. Boss Nature vol. 303 26 May 1983, pp. 281 282.Boss, "Enhancer Elements in Immunoglobulin Genes," Nature v. 303 pp. 281-282 (1983)....
it was widely believed that transcription factors are sufficient to program developmentalontogeny, and the role of DNA andhistonemodifications in gene regulation was not yet appreciated, as David Allis later recalled [113]. Of note were the widely accepted assertions of Mark Ptashne, who declared ...
Recent studies revealed that the transcription of eRNAs may be a biological marker responding to enhancer activity that can participate in the regulation of coding gene transcription. In this review, we discussed the biological characteristics of eRNAs, their functions in transcriptional regulation, the ...
Our analyses thus far have focused on the assessment of distal gene regulation. However, often the goal is to assess the functional regulation from anywhere in the genome, including binding both distal and proximal to TSSs. One commonly used method for ChIP-seq GSE testing is to link all peak...
Cell-specific and shared enhancers control a high-density multi-gene locus active in mammary and salivary glands Regulation of high-density loci harboring genes with different cell-specificities remains a puzzle. Here we investigate a locus that evolved through gene d... H. Lee,M. Willi,Chengyu...
analysis gene expression) profiles in the FANTOM5 project [10,15,16]. Only a small portion of enhancers, however, has been characterized, underscoring the importance of accurate identification of active enhancers to study their transcriptional regulation and understand their role in regulating gene ...
Motivation:Enhancer-Promoter Interactions (EPIs) is an essential step in the gene regulation process. However, the detection of EPIs by traditional wet experimental techniques is time-consuming and expensive. Thus, computational methods would be very useful for understanding the mechanism of EPIs. A ...
Gene activation by metazoan enhancers: diverse mechanisms stimulate distinct steps of transcription. BioEssays 38, 881–893 (2016). CAS PubMed Google Scholar Lenhard, B., Sandelin, A. & Carninci, P. Metazoan promoters: emerging characteristics and insights into transcriptional regulation. Nat. ...