The cis-isomers of compounds 10 and 12 and trans-13 were readily transformed to gem-difluoromethylenated dihydroxypyrrolizidines 20 and 27 and indolizidine 28, respectively, by reductive cleavage of the hydroxyl group and organometallic addition followed by hydrogenolysis. 展开 ...
Transformation of gem-dimethylcyclopentane and gem-dimethylcyclohexane on group VIII noble metals1. The behavior of gem-dimethylcyclopentane in a discontinuous system at 200–340°C in the presence of Pt, Rh, Rr, Ir, Os, and Pd deposited on active carbon is similar to the behavior of......
Treatment with Bu n Li in THF (−60–0°C) causes 4-methyl-4-trichloromethylcyclohexa-2,5-dien-1-one and its exo -η 4 -coordinated (by a RhCp-group) π-... S Sergeev,V Nikanorov,D Zverev,... - 《Russian Chemical Bulletin》 被引量: 4发表: 1997年 Silicon monophosphide as ...
groupatthevpositionofthelactoneringwouldlcadtofostriecinanalogue4withenhancedenzymaticbindingaffinity.Ac— cordingly.thesynthesisoffostriecinanalogue4wasinvestigated.Theskeletonoftargetmolecule4wasestablishedconver— gentlyfromfragmentsa,bandcviaanmagnesiummediatedchelation—controlledadditionandStillecouplingusing Pd(CH...
Chemical Communications Royal Society of ChemistryUrbina-Blanco CA, Skibinski M, O'Hagan D, Nolan SP. Accelerating influence of the gem- difluoromethylene group in a ring-closing olefin metathesis reaction. A Thorpe-Ingold effect? Chem. Commun. 2013;49(65):7201-7203....
Fluoride-catalyzed nucleophilic addition of a difluoro(phenylsulfanyl)methyl group ("PhSCF2 ") generated from PhSCF2 SiMe3 to nitrones was accomplished in satisfactory yields. High diastereoselectivities were observed with chiral polyoxygenated cyclic nitrones to provide the corresponding adducts, which...
CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRYUrbina-Blanco CA, Skibinski M, O'Hagan D, Nolan SP. Accelerating influence of the gem- difluoromethylene group in a ring-closing olefin metathesis reaction. A Thorpe-Ingold effect? Chem. Commun. 2013;49(65):7201-7203....
Gem-Difluoromethylene GroupThe article mainly argues with the latest progress of methodologies which is the introduction of a difluoromethylene unit into the organic compounds. It will also summarize the theoretical study of introducing gem-difluoromethylene group into the organic molecular. Firstly,...
Our studies permit the assignment of the lower field resonance to the endo-methyl group and the higher field resonance to the exo-methyl group of the dimethyldioxolanes.doi:10.1080/00387016908050049Sable, Henry Z.Ritchey, William M.Nordlander, J. Eric...
A.EaStCHEMSkibińskiEaStCHEMMaciejEaStCHEMO'HaganEaStCHEMDavidEaStCHEMNolanEaStCHEMStevenEaStCHEMP.EaStCHEMEBSCO_AspChemical CommunicationsUrbina-Blanco CA, Skibinski M, O'Hagan D, Nolan SP. Accelerating influence of the gem- difluoromethylene group in a ring-closing olefin metathesis reaction. A ...