The first indication that GDP-fucose, like other nucleotide sugars, is transported by a carrier-mediated process was obtained by Sommers and Hirschberg (1982). The gene encoding the GDP-fucose transporter was identified independently by two groups using complementation cloning in patient-derived cells...
2016. Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies. Biotechnol J 11:399 - 414. https:// doi.org/10.1002/biot.201500331.K.F. Chan, W. Shahreel, C. Wan, G...
The gene encoding the GDP-fucose transporter was identified independently by two groups using complementation cloning in patient-derived cells (Lübke et al. 2001; Lühn et al. 2001). These patients were suffering from leukocyte adhesion deficiency II (LAD II), also known as congenital disorder ...
Nucleotide sugar transport across Golgi membranes is essential for the luminal biosynthesis of glycan structures. Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide sugar transporter that translocates GDP-L-fucose into the Golgi
Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide sugar transporter that translocates GDP-L-fucose into the Golgi lumen. Using proteo-liposome-based transport assays, we show that GFT preferentially transports GDP-L-fucose over other nucleotide sugars in vitro, while GFT1...
来源期刊 Nature Genetics 研究点推荐 GDP-fucose transporter 站内活动 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。了解更多>> 友情链接 ...
Complementation cloning identifies CDG-IIc, a new type of congenital disor- ders of glycosylation, as a GDP-fucose transporter deficiency. Nat Genet 2001; 28:73e6.Lubke T, Marquardt T, Etzioni A, Hartmann E, von Figura K, Korner C. 2001. Complementation cloning identifies CDG-IIc, a new ...
In humans, the mutation of a GDP-fucose transporter is responsible for an impaired immune response as well as retarded growth. These results suggest that, even though there appear to be a fair number of genes encoding for NSTs, ... M Handford,C Rodriguez-Furlán,A Orellana - 《Brazilian ...
It also provides yeast cells expressing bifunctional enzyme fucosyltransferase and / or GDP-L- fucose transporter. Furthermore, the yeast comprises one or more expression cassettes for the fusion protein and ER / Golgi retention sequence and a heterologous glycosylation pathway. Finally, the invention ...
Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide sugar transporter that translocates GDP- L -fucose into the Golgi lumen. Using proteo-liposome-based transport assays, we show that GFT preferentially transports GDP- L -fucose over other nucleotide sugars in vitro , ...