The first indication that GDP-fucose, like other nucleotide sugars, is transported by a carrier-mediated process was obtained by Sommers and Hirschberg (1982). The gene encoding the GDP-fucose transporter was identified independently by two groups using complementation cloning in patient-derived cells...
The Arabidopsis Golgi-localized GDP-L- fucose transporter is required for plant development. Nat Commun 2016; 7:12119; PMID:27381418; http://dx.doi. org/10.1038/ncomms12119C. Rautengarten, B. Ebert, L. Liu, S. Stonebloom, A.M. Smith-Moritz, M. Pauly, et al., The Arabidopsis Golgi...
The gene encoding the GDP-fucose transporter was identified independently by two groups using complementation cloning in patient-derived cells (Lübke et al. 2001; Lühn et al. 2001). These patients were suffering from leukocyte adhesion deficiency II (LAD II), also known as congenital disorder ...
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We have previously identified the genetic defect of LAD II in a patient whose Golgi GDP-fucose transporter (GFTP) bears a single amino acid exchange that renders this protein nonfunctional but correctly localized to the Golgi. We now report a novel dual defect by which a truncated GFTP causes...
Lubke T, Marquardt T, Etzioni A, Hartmann E, von Figura K, Korner C. Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Nat Genet 28:73-76, 2001.
In humans, the mutation of a GDP-fucose transporter is responsible for an impaired immune response as well as retarded growth. These results suggest that, even though there appear to be a fair number of genes encoding for NSTs, ... M Handford,C Rodriguez-Furlán,A Orellana - 《Brazilian ...
These results strongly suggest that GFT1 may be the only GDP-Fuc transporter in Arabidopsis. It was generally assumed that the structural alterations to RG-II in the mur1 mutant were mainly due to the substitution of L-fucose by L-galactose35; however, it now appears that the altered ...
Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene LA, Cunningham-Rundles C, Frenette PS (2003) Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene... Hidalgo,A. - 《Blood》 被引量...
Nucleotide sugar transport across Golgi membranes is essential for the luminal biosynthesis of glycan structures. Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide sugar transporter that translocates GDP-L-fucose into the Golgi