The first indication that GDP-fucose, like other nucleotide sugars, is transported by a carrier-mediated process was obtained by Sommers and Hirschberg (1982). The gene encoding the GDP-fucose transporter was identified independently by two groups using complementation cloning in patient-derived cells...
Nucleotide sugar transport across Golgi membranes is essential for the luminal biosynthesis of glycan structures. Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide sugar transporter that translocates GDP-L-fucose into the Golgi
Purification of the Rat Liver Golgi Membrane GDP-fucose Transporter All of the operations described below were performed at 4 °C. Step 1: Detergent Extraction A purified Golgi fraction was prepared from 250 g of frozen rat livers according to the procedure of Leelavathi et al. (17). This ...
In fibroblasts from five patients with carbohydrate-deficient glycoprotein syndrome type 1, the incorporation of [2–3H] mannose into mannose phosphates, GDP-mannose, GDP-fucose, dolichol-P-mannose, lipid-linked oligosaccharides, and glycoprotein fraction was determined. We observed a 3- to 5-fold ...
We have previously identified the genetic defect of LAD II in a patient whose Golgi GDP-fucose transporter (GFTP) bears a single amino acid exchange that renders this protein nonfunctional but correctly localized to the Golgi. We now report a novel dual defect by which a truncated GFTP causes...
www.nature.com/scientificreports OPEN The disruption of GDP-fucose de novo biosynthesis suggests the presence of a novel fucose- received: 21 July 2016 containing glycoconjugate inaccepted:03October2016 Published:16November2016 Plasmodium asexual blood stages Sílvia Sanz1,*, Borja López-Gutiérrez...
3'-Diaminobenzidine (GDP)--l-fucose by the bifunctional l-fucokinase/GDP--l-Fuc pyrophosphorylase of Bacteroides fragilis 9343.AIMS: Fucosylation is regulated by fucosyltransferases, the guanosine diphosphate-L-fucose (GDP-L-Fuc) synthetic pathway, and the GDP-L-fucose transporter (GDP-L-Fuc Tr...
(2006) Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII. Apmis, 114, 539-548.Niittymaki J, Mattila P, and Renkonen R 2006. Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter ...
(2000). GDP-fucose uptake into the Golgi 945 apparatus during xyloglucan biosynthesis requires the activity of a transporter-like protein 946 other than the UDP-glucose transporter. Plant Physiol. 122: 867-877.WulV C, Norambuena L, Orellana A (2000) GDP-fucose uptake into the Golgi apparatus...
Ablation of the GDP-fucose transporter suppresses lung cancer cell proliferation and migration by reducing expression of PD-L1doi:10.7150/jca.84652ABLATION techniquesGROSS domestic productLUNG cancerCELL proliferationFUCOSYLATIONYingshu ZhangNianzhu Zhang...