乳腺癌组织的GATA6-AS1水平和临床意义
Besides tumor suppressor, GATA6-AS1 serves as a miR-543 sponge. Specifically speaking, GATA6-AS1 acts as a competing endogenous RNA (ceRNA) of miR-543 to upregulate the expression of PTEN, thus inactivating AKT signaling pathway to inhibit GC progression. In conclusion,...
目的:长非编码RNAGATA6-AS1与肿瘤发生及发展密切相关,但是其在胃癌的表达以及对胃癌发生及发展中的作用目前尚未完全清楚.本研究拟通过细胞生物学实验研究GATA6-AS1对胃癌细胞增殖,侵袭及迁移的影响,并初步探讨其可能的作用机制,为胃癌早期诊断及精准治疗提供依据.方法:用生物信息学方法分析癌症基因组图谱数据库(https:...
GATA6-AS1 inhibited the expression of fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A) eraser, and repressed SNAI1 mRNA stability in an m6A-dependent manner. Our data suggested that GATA6-AS1 can inhibit PDAC cell proliferation, invasion, migration, EMT process and ...
Knockdown of GATA6-AS1 in human pluripotent stem cells has no influence on morphology and pluripotency; however, GATA6-AS1 depletion causes the deficiency of definitive endoderm differentiation. GATA6-AS1 positively regulates the expression of endoderm key factor GATA6. Further investigation shows GATA...
GATA6-AS1 is adjacent to cardiac transcription factor GATA6. We found that GATA6-AS1 was nuclear-localized and transiently upregulated along with GATA6 during the early stage of cardiomyocyte differentiation. The knockdown of GATA6-AS1 did not affect undifferentiated cell pluripotency but inhibited ...
GATA6-AS1MiR-4530GATA6Lung adenocarcinomaBackground Lung adenocarcinoma (LUAD) is known to be one of the leading causes of cancer-related deaths globally. In recent decades, long non-coding RNAs (lncRNAs) have been indicated to exert pivotal regulating functions in multiple biological behaviors in...
GATA6-AS1 in gastric cancer tissue and normal tissue.We also constructed a GATA6-AS1 lentivirus overexpression vector which was transfected into gastric cancer cells to investigate its effects on proliferation,migration and invasion,and thereby clarify the expression of GATA6-AS1 in gastric cancer ...
Overexpressed long non-coding RNA GATA6-AS1 inhibits lymph node metastasis and epithelial mesenchymal transition via FZD4 through the Wnt/β-catenin signaling pathway in gastric cancerdoi:10.1016/j.omtn.2019.09.034Zheng Tian LiXu ZhangDw Wang...