LncRNA GATA3-AS1是一种新型反义LncRNA,与T细胞发育和分化有关[14]。GATA3-AS1已被证实可促进肝细胞癌的细胞增殖和迁移[15],但其在乳腺癌中的作用及其机制报道较少,因此本文拟研究GATA3-AS1在乳腺癌中的生物作用并对其分子机制进行...
Upregulation of GATA3-AS1 was revealed in PC tissues and cell lines. Knockdown of GATA3-AS1 in PANC-1 or AsPC-1 cells markedly reduced cell viability, cell proliferation, and cell invasion abilities, while cell apoptosis was increased. In addition, GATA3-AS1 knockdown suppressed the stemness...
Based on data from public databases, GATA3-AS1 was identified as upregulated in bladder urothelial carcinoma (BLCA); however, its exact function and regulatory mechanism in this context remain unclear. Methods: To investigate the clinical implications of GATA3-AS1, we examined its levels i...
GATA3-AS1Ovarian Cancer5-Fluorouracil ResistancemiR-6771-3pSOX4Ovarian cancer (OC) ranks as the 5th highest cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) exert significant effects on chemotherapy resistance. The effects of lncRNA GATA3-AS1 on the 5-Fluorouracil (5-...
本发明试剂盒包括扩增miR1243p,GATA3AS1和内参U6的上下游引物,这些引物序列如SEQ ID NO.16所示.利用本发明试剂盒,通过实时荧光定量PCR检测待测者血清中hasmiR1243p与GATA3AS1的相对表达量,若待测者血清中hasmiR1243p相对表达量与正常人之比低于0.56,且GATA3AS1相对表达量与正常人之比高于1.56,则待测者患有胃癌...
lncRNA GATA3-AS1靶向miR-515-5p对儿童急性淋巴细胞白血病细胞增殖和凋亡的影响doi:10.19746/j.cnki.issn1009-2137.2023.04.016秦彦韵雪雪郑忠梅徐倩左立旻Journal of Experimental Hematology / Zhongguo Shiyan Xueyexue Zazhi
GATA3 antisense RNA 1 ( GATA3-AS1 ) is an lncRNA gene neighboring GATA binding protein 3 ( GATA3 ). The current study aims to quantitatively compare the levels of the expression of GATA3-AS1 , GATA3 , and Interleukin-4 ( IL-4) in peripheral blood mononuclear cells (PBMC) samples of...
lncRNA GATA3-AS1 has been identified as an oncogene in various cancers. However, the functions and mechanisms of GATA3-AS1 in EC remain to be explored. Human EC tissues and four EC cell lines were used. Western blotting and quantitative real-time PCR (qRT-PCR) were used to evaluate the...
GATA3-AS1+anti-mi R-515-5p共6组.CCK-8法检测细胞增殖,流式细胞术分析细胞凋亡,双荧光素酶报告实验用于确定GATA3-AS1和mi R-515-5p的靶向关系.结果:ALL患儿血浆中GATA3-AS1表达水平显著高于对照者(P<0.001),mi R-515-5p表达水平显著低于对照者(P<0.001).与si-NC组比较,si-GATA3-AS1组细胞抑制...