Here we found a long non-coding RNA, GATA2-AS1, repressing NSCLC cells proliferation via regulating GATA2. GATA2-AS1 gene is located at antisense strand of GATA2 on chromosome while GATA2-AS1 RNA interacts with GATA1 protein at promoter region of GATA2 and then ...
GATA2-AS1的表达情况.应用小干扰RNA(siRNA)沉默HCT116细胞中lncRNA GATA2-AS1的表达,通过CCK-8法,EdU增殖实验,划痕实验,Transwell侵袭实验检测lncRNA GATA2-AS1对结直肠癌细胞增殖,迁移和侵袭的影响.采用Western blot法检测上皮间充质转化相关蛋白表达情况.结果结直肠癌细胞的lncRNA GATA2-AS1表达水平与正常肠黏膜...
Results:The expression of GATA2-AS1 and PTPN12 was reduced, while miR-940 expression was enhanced in ESCC tissues and cell lines. In vivo experiments showed that GATA2-AS1 inhibited the progression of ESCC cells toward malignancy. Bioinformatics analysis, dual luciferase and RIP assays revealed ...
GATA2-AS1GATA2DDX3XColorectal cancer (CRC) is a common malignant tumor with a high risk of metastasis. Long non-coding RNAs (lncRNAs) have been reported to be implicated in cancer progression via regulating its nearby gene. Herein, we investigated the function of GATA binding protein 2 (GATA...
methyladenosine methylation, GATA2-AS1 bound with far upstream element binding protein 3 (FUBP3) to repress its liquid-liquid phase separation and interaction with suppressor of zest 12 (SUZ12), resulting in decrease of SUZ12 activity and epigenetic up-regulation of GATA2 and other tumor ...