该基因编码一个锌指转录因子GATA家族的成员,该家族以它们在靶基因启动子区域结合的一致核苷酸序列命名。编码蛋白在调节参与造血和内分泌细胞谱系发育和增殖的基因转录中起着重要作用。选择性剪接导致多个转录变体。This gene encodes a member of the GATA family of
Charles[4]等研究人员在Gata2基因5号外显子两侧插入loxp位点，产生Gata2flox/flox小鼠（图3）。图3 Gata2flox/flox小鼠构建方式[4]Onodera[1]等人将Gata2flox/flox与ER-Cre小鼠杂交，产生树突状细胞（DC）特异性Gata2敲除小鼠（Gata2flox/flox/ER-Cre）。研究结果表明，杂交后代DC中几乎检测不到Gata2 mRNA表达...
GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene. Mol. Cell. Biol. 25, 7005-7020.Kobayashi-Osaki M, Ohneda O, Suzuki N, Minegishi N et al (2005) GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene. Mol Cell Biol 25...
O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018 Oct;142(4):1173...
图1 Gata2基因相关信息来源:RDDC罕见病数据中心(https://rddc.tsinghua-gd.org/details/gene?gene=mMKVgG) 图2 Gata2蛋白结构(https://alphafold.ebi.ac.uk/entry/O09100) Gata2相关疾病介绍 Gata2基因参加调节树突状细胞的分化、造血干细胞的增殖、IgE/肥大细胞的分化、粒细胞-单核细胞祖细胞的分化等多种...
[5] Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE...
[5] Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE...
[5] Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE...
[5] Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE...
W ang M ing.chun ,W .Siegcrt@, C A.Schmid ① Dept.ofHematol ogy.J 啪￡ it y.Guwtvzhou 510632 @ Dept.ofHem atology andOncology R,~ol f w Hospit at.Berlin 13351, Germany Keywortl* tanscriptionfactor,genepomtmutation,leukemia 一 耙 一一一 一一一一一一 维普资讯 http://www.cqvip...