Gastrointestinal stromal tumors (GISTs) are a rare type of tumor that can develop liver metastasis (LIM), significantly impacting the patient's prognosis. This study aimed to predict LIM in GIST patients by constructing machine learning (ML) algorithms to assist clinicians in the decision-making pr...
Gastrointestinal stromal tumours (GISTs) are rare, yet the most common mesenchymal tumour within the digestive tract. Lack of diagnostic criteria and no specific code in the ICD system has prevented epidemiological evaluation except from overt malignant cases in the past. A global estimate of incidenc...
Most gastrointestinal stromal tumors (GIST) harbor mutations in either the KIT proto-oncogene (KIT[OMIM 164920]; 80%) or platelet-derived growth factor receptor a (PDGFRA[OMIM 173490];15%) receptor tyrosine kinases1,2,3. However, up to 10% of GIST are found to have non-mutatedKITandPDGFRA...
Materials/Methods Gastrointestinal stromal sarcoma (ICD-O-3 8936/3) data was obtained from SEER*STAT version 8.4.0.1 for the period 2000-2019. Codes pulled included age, sex, primary tumor localization, surgical status, & overall survival. Geriatric age was defined as ≥70 years. Statistical ...
The epithelial cells of the gastrointestinal (GI) tract communicate with each other and with cells of other organs via a complex network of highly regulated movement of ions and biomolecules. The molecules ensure regulated activity of cells, tissues, and
Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single-cell transcriptomics in real-world pancreatic cancer biopsies Clin Cancer Res, 27 (2021), pp. 5912-5921 CrossrefView in ScopusGoogle Scholar 28 Jiang H., Yu D., Yang P., Guo R., Kong M., Gao Y., ...
gastrointestinal stromal tumors;GIST;C-Kit;imatinib mesylate;survival 1. Introduction Gastrointestinal stromal tumors (GIST) are rare non-epithelial tumors derived from mesenchymal tissues. They originate from interstitial Cajal cells or the stem cell precursors of these cells, located around the myenteric...
Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers. Int J Oncol. 2009;34(3):619–27. Article CAS PubMed Google Scholar Deng L, Jiang N, Zeng J, Wang Y, Cui H. The versatile roles of cancer-associated fibroblasts in colorectal cancer and ...
The GEPIA database evaluated the expression of specific markers linked to immune cell infiltration as well as the relationship between NOTCH3 expression and patient prognosis in a variety of tumour types. Other genes of interest were displayed on the y-axis, while NOTCH3 was utilized for the x...