Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Most result from activating mutations in the KIT (CD117) proto-oncogene or in the platelet-derived growth factor receptor alpha gene ( PDGFRA ). They can arise in any location through...
Therefore, STI571 was examined for therapeutic efficacy against malignant Gastro-Intestinal Stromal Tumors (GIST), which are mainly caused by aberrant expression of a mutated c-Kit that is constitutively active without binding of a ligand, stem cell factor (SCF). More than a half of the ...
9. metastatic [ˌmetə'stætɪk] adj. 转移性的 10. Gastrointestinal stromal tumor=GIST 胃肠道间质瘤; gastrointestinal [ˌgæstroʊɪnˈtestɪnl] adj. 胃与肠的 stromal [ˈstrəʊməl] adj. 基质的 11. mesenchymal [mes'eŋkɪməl] adj. 间叶细胞的 12. n...
虽然作为一种少见病,胃肠间质瘤(gastrointestinal stromal tumor, GIST)的发病率远不能与消化道更常见的胃癌、肠癌相提并论,但是由于其独特的发病机制及其卓越有效的靶向药物治疗,GIST成为这个世纪以来最经典的精准医疗背景下靶向治疗的成功典型,也吸引了一批致力于GIST临床与基础研究的学者。回顾刚刚过去的2019年,GIST研...
Gastrointestinal Stromal Tumor 2022; 5: 8 (10 November 2022) PDFFull Text(1013)COI FormOpen Access Review Article A narrative review of minimally invasive techniques for treatment of gastric gastrointestinal stromal tumors Paolo Pizzini,Sara Coppola,Filippo Ascari,Michele Manara,Stefano De Pascale ...
10. Gastrointestinal stromal tumor=GIST 胃肠道间质瘤; gastrointestinal [ˌgæstroʊɪnˈtestɪnl] adj. 胃与肠的 stromal [ˈstrəʊməl] adj. 基质的 11. mesenchymal [mes'eŋkɪməl] adj. 间叶细胞的 12. neoplasm ['ni:oʊplæzəm] n. 肿瘤; 新生物 ...
10. Gastrointestinal stromal tumor=GIST 胃肠道间质瘤; gastrointestinal [ˌgæstroʊɪnˈtestɪnl] adj. 胃与肠的 stromal [ˈstrəʊməl] adj. 基质的 11. mesenchymal [mes'eŋkɪməl] adj. 间叶细胞的 12. neoplasm ['ni:oʊplæzəm] n. 肿瘤; 新生物 ...
Joensuu H: Gastrointestinal stromal tumor (GIST). Annals of Oncology. 2006, 17 (10): 280-286. 10.1093/annonc/mdl274. Article Google Scholar Mazur MT, Clark HB: Gastric stromal tumors: Reappraisal of histogenesis. Am J Surg Pathol. 1983, 7: 507-519. Article CAS PubMed Google Scholar ...
c-Kit/PDGFRA Gene Status Alterations Possibly Related to Primary Imatinib Resistance in Gastrointestinal Stromal Tumors Purpose: To correlate morphologic changes with molecular, biochemical, and cytogenetic profiles in gastrointestinal stromal tumor (GIST) patients before an... F= Miselli,P Casieri,T Neg...
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