Inhibition of gamma-secretase presents a direct target for lowering Aβ production in the brain as a therapy for Alzheimer's disease (AD). However, gamma-secretase is known to process multiple substrates in addition to amyloid precursor protein (APP), mo
Thus, we next determined whether Pip5k1c knockdown (KD) by siRNA affects the intracellular Ca2+ levels traced by fluo-4/AM, a probe for cytoplasmic Ca2+. As expected, the fluorescence intensity was decreased in BMSCs with Pip5k1c KD compared to that in BMSCs treated with control siRNA (...