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Therapeutic effects of acylated ghrelin-specific receptor GHS-R1a antagonist in islet transplantation Article Open access 28 October 2021 The metabolic effects of adding exenatide to basal insulin therapy when targeting remission in early type 2 diabetes in a randomized clinical trial Article Open ac...
In addition, seizures caused by PTZ, a GABA receptor antagonist, induced synaptic loss and neuronal death in the hippocampus of APP mice. Pyramidal neuronal hyperexcitability might underlie epileptogenesis in mouse brain. We found that hippocampal GABAergic but not glutamatergic transmission was ...
aScheme illustrating the five different protocols tested for their potential to yield the highest amount of neurons and glia in BENO cultures: (1) Dual SMAD inhibition (SB/noggin) in the presence of RA during culture days 0–10; (2) FGF-2 treatment to enhance neuronal progenitor number durin...
GABA-ergic drugsInteractionThe interaction of Ro 15-1788 (5 mg kg 1 i.p.), a benzodiazepine antagonist, with GABA-ergic drugs muscimol (1.4 mg kg 1 i.p.), fenibut (100 mg kg 1 i.p.) and baclofen (5 mg kg 1 i.p.) was examined in behavioural and biochemical studies in rats....
A reappraisal of its pharmacological properties and therapeutic efficacy as a benzodiazepine antagonist. Drugs 42(6):1061–1089 Article CAS PubMed Google Scholar Spivey WH (1991) Flumazenil and seizures: analysis of 43 cases. Clin Ther 14(2):292–305 Google Scholar Kavvadias D, Sand P, You...
All these compounds are ionized at pH 7.4. In order to determine the effect of the ligand charge on the antagonist-receptor interaction, a current-voltage ramp protocol was performed from −120 to +70 mV in presence of the IC50concentration for each compound (n = 6 oocytes, Suppleme...
Iomazenil produces a net deficit in GABA function; in preclinical studies, it has been shown to behave as a BZR-competitive antagonist with inverse agonist effects (Beer et al, 1990; Hoffmann-La Roche; Schubiger and Hasler, 1989), and in clinical studies, it has been shown to have ...
mediated hippocampal theta neural synchronisation as a readout. The GABAergic inhibition was manipulated by intraseptal microinjection of bicuculline, an antagonist at GABAAreceptors. Note, that separate group of animals were used for open field (Figs 1and2a,b) and formalin experiments (Fig. 2c,...
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