结果 十二烷 基硫酸钠 - 聚丙烯酰氨凝胶电泳(sodium dodecyl sulfate-polyacrylamide gel electropheresis,SDS-PAGE), Western Blot 结果表明,纯化后的蛋白分子量大小约为 38.2 kDa,符合 HLA-G1 蛋白的分子量 ;人 PBMC 与 HLA-G1 蛋白共培养后,随着 HLA-G1 蛋白浓度的升高(浓度梯度 :0,50,100 和 200 ng...
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G1 is the initial phase of the cell cycle when cells must acquire all the necessary information to proceed safely into the next phase, S, when theirgeneticdowry has to be faithfully duplicated. Cells enter G1 either after completing cytokinesis if they are actively proliferating (M/G1 transiti...
1A). Already 45 minutes after release the rad3Δ cells have synthesized more DNA than wild-type cells and thus progressed further into the cell cycle. The time difference between rad3Δ and wild-type cells is about 15 minutes, which is a substantial difference, considering that the ...
Tumor cells on the other hand have a defective G1 checkpoint and only arrest in S phase with high concentrations of UCN-01. The effect of UCN-01 on the cell cycle is thus quite different from staurosporine, a structural analogue of UCN-01, which arrests normal cells in both G1 and G2...
Surge G1 monitors the slight change in the internal materials of mobile phone cells caused by drops, and collisions with its ISP(Image Signal Processing) function. It also is able to dynamically analyze the reasonable temperature range of the battery under charging and discharging scenarios based ...
cells arrest in G1 but also how these cells then respond to the arrest. A positive response is often associated with markedtumor regressionthat is sustained after chemotherapy has ceased, implying that tumor cells experience a cytotoxic response to these drugs and not simply acytostaticG1 arrest....
In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency. This is a preview of subscription content, log in via an institution to check access. References Liu, L. et al. Nat. ...
Zhang W, Grasso L, McClain CD,et al: p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.Cancer Res 55:668–674, 1995. PubMed CAS Google Scholar Jiang H, Lin J, Su Z-Z,et al: Induction of diffe...
Inhibition of proliferation and induction of G1-phase cell-cycle arrest by dFMGEN, a novel genistein derivative, in lung carcinoma A549 cells. Drug Chem Toxicol 2013; 36:196-204.Peng B, Cao J, Yi S, Wang C, Zheng G, He Z. Inhibition of prolifera- tion and induction of G1-phase ...