首先,我们可以把一个细胞的周期分为间期interphase以及分裂期celldivision phase. 其中interphase是在做一些准备工作,而celldivision phase则是真正的在分裂 当然 ,事情并没有这么简单。 每一个phase接下来都可以更细节的分为几个阶段。 Interphase G0/G1phase -A resting phase -Cell perform own function -Some typ...
[9] Shi Y, Chen G, Wang X, et al. Furmonertinib (AST2818) versus gefitinib as first-line therapy for Chinese patients with locally advanced or metastatic EGFR mutation-positiv non-small-cell lung cancer (FURLONG):a...
IL-12-dependent innate immunity arrests endothelial cells in G0-G1 phase by a p21(Cip1/Waf1)-mediated mechanism.AngiogenesisCell proliferationCytokinesSignal transductionT cellsan inhibitor of cyclin kinases. This effect requires the activation of STAT1, PKC未 and p38 MAPK, while p53 is ineffective...
The decision to replicate its DNA is of crucial importance for every cell and, in many organisms, is decisive for the progression through the entire cell cycle. A comparison of animals versus yeast has shown that, although most of the involved cell-cycle regulators are divergent in both clades...
PDCD4, the protein encoded by the tumor suppressor gene PDCD4 (programmed cell death 4) has been implicated in the control of cellular transcription and translation by modulating the activity of specific transcription factors and suppressing the translat
2015年初,李国红课题组的前期研究发现了CENP-A分子的Ser68的磷酸化/去磷酸化参与调节细胞G1期CENP-A在着丝粒区的装配(Yu et al., Development Cell, 2015),清楚地揭示了CENP-A如何装配到着丝粒区。 在以上研究的基础上,李国红课题组又对CENP-A装配到着丝粒区后如何调节染色质结构及发挥着丝粒功能进行了重点研究。
Owa, T.; Yoshino, H.; Yoshimatsu, K.; Nagasu, T. Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. Curr. Med. Chem. 2001, 8, 1487-1503.Owa T, Yoshino H, Yoshimatsu K, Nagasu T. Cell cycle regulation in the G...
In our screen, HJURP is not a prominent contributor to overall CENP-A maintenance, relative to SENP6 or other candidate maintenance factors (Supplementary Data 2). Nevertheless, S phase may be a critical cell cycle window where CENP-A maintenance requires the re-assembly of pre-existing CENP-...
Transfer these cells to the centrifuge tube from Step 1. Centrifuge at 125 x g for 5 to 10 minutes. Remove medium and resuspend pellet in fresh complete medium. Add appropriate aliquots of cell suspension to new culture vessels. Incubate cultures at 37°C. Subcultivation ratio: A ...
MRC-5 (人胚肺细胞) (STR鉴定正确)细胞系别称 MRC5; MRC 5; MRCV; MRC-V; Medical Research Council cell strain-5种属 人类 RD (人恶性胚胎横纹肌瘤细胞) (STR鉴定正确)细胞系别称 R D; RD-2; RD 2; 130T; 130-T; 130 T; TE-32; TE 32; TE32; TE 32.T; Te 32.T种属 人类 注意事...