Expression of G1-phase cell cycle genes during hematopoietic lineage. Biochem Biophys Res Commun 1997;231:73-76.Della, R.F., A. Borriello, S. Mastropietro, P.V. Della, F. Monno, V. Gabutti, F. Locatelli, L. Bonsi, G.P. Bagnara, and A. Iolascon. 1997. Expression of G1- ...
The G1 Phase Cell Cycle Checkpoint refers to a stage in the cell cycle where cells in the G1 phase are prevented from entering the S phase in the presence of DNA damage, inhibiting the initiation of DNA replication. AI generated definition based on: Encyclopedia of Biological Chemistry (Secon...
Nagasu.Cell Cycle Regulation in the G1 Phase: A Promising Target for the Development of New Chemotherapeutic Anticancer Agents.Current Medicinal Chemistry. 2001Owa,T.,Yoshino,H.,Yoshimatsu,K.Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic ...
We demonstrate that notwithstanding cyclin D1 expression increase, cell cycle progression is compromised in the G1 phase due to reduced phosphorylation of the pocket protein p130 leading to inhibition of transcription factors of the E2F family which are crucial for cell cycle progression and DNA ...
Western blotting analysis showed that WPBFE could cause the arrest of cell cycle in G0/G1 phase by down-regulating expression levels of PCNA, CDK4, cyclin D1 and up-regulating the expression level of p21. Meanwhile...
Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA replication is one of the most sensitive processes and therefore all organisms carefully regulate
Before replicating DNA during their reproductive cycle, our cells enter a phase called G1 during which they interpret a flood of signals that influence cell division and cell fate. Mistakes in this process lead to cancer. An increasingly complex and coherent view of G1 signalling networks, which...
G1 phase arrest induced by IFN-λ1 To explain the mechanism of cell growth inhibition by IFN-λ1 concerning cell cycle change, we analyzed the effects of IFN-λ1 treatment on the cell cycle. As shown inTable I, the percentage of cells in the G1 phase increased, whereas the percentage ...
cell cycle and sub-G1 represented in bar graphs,n=3 per treatment group. Significance of G1-phase cell cycle arrest, where *P<0.05, **P<0.01, ***P<0.001, determined by ANOVA followed by the Tukey multiple comparison procedure where a=untreated, b=SIM, c=MET, and d=SIM+MET in ...
To study the potential function of LIF in the downregulation of gastric cancer, we monitored the behavior using proliferation, cell cycle, and flow cytometry analysis. Overexpression of LIF inhibited the gastric cancer cell cycle in the G1 phase. In our experiment, overexpression of LIF by ...