Cell CycleLezaja, A.; Altmeyer, M. Inherited DNA lesions determine G1 duration in the next cell cycle. Cell Cycle 2018, 17, 24-32. [CrossRef] [PubMed]Lezaja, A. & Altmeyer, M. Inherited DNA lesions determine G1 duration in the next cell cycle. Cell Cycle 17, 24-32 (2018)....
近日,该联合攻关团队通过建立mettl16基因敲除的斑马鱼,解析了Mettl16通过m6A读取器Igf2bp1调控mybl2bmRNA的稳定性控制HSPCs的G1/S细胞周期进程,该研究揭示了Mettl16基于m6A调控HSPC细胞周期进程的分子机制,相关工作以“AMettl16/m6A/Mybl2...
2021年4月,加拿大University Ave和中国香港大学团队与癌症研究所表观遗传学和基因组稳定性小组在Cell Death & Differentiation 杂志上发表了文章“The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in...
The G1 checkpoint is a critical control point in the cell cycle that occurs at the end of the G1 phase, just before the cell enters the S phase and begins DNA replication. From:Pathology - Research and Practice,2023 About this page ...
Arrest of cultured cells in the G1 phase of the cell cycle by indomethacin. Indomethacin reversibly inhibited growth of rat hepatoma cells (HTC) and human diploid fibroblasts in the G1 phase of the cell cycle. Cytophotometric measurements showed that greater than 90% of cells incubated for 48...
Please provide two examples explain the importance of protein phosphorylation in cell cycle regulation.【参考回答】：不同的cyclin-CDK复合物，通过CDK活性，催化不同底物磷酸化，这些效应的最终结果使细胞周期不断运行，而实现对细胞周期不同时相的推进和转化作用。（1）激活的 CDK1 可将核纤层蛋白磷酸化导致...
Owa T, Yoshino H, Yoshimatsu K, Nagasu T (2001), Cell cycle regulation in G1 phase: A promising target for the development of new chemotherapeutic anticancer agents, Curr. Med. Chem. 8: 1487-1503Owa T, Yoshino H, Yoshimatsu K, Nagasu T. Cell cycle regulation in the G1 phase: a ...
Schnebli, HP, Haemmerli, G (1974) Protease inhibitors do not block transformed cells in the G1 phase of the cell cycle. Nature 248: pp. 150Schnebli HP, Haemmerli G. Protease inhibitors do not block transformed cells in the G1 phase of the cell cycle. Nature. 1974 Mar 8; 248 (...
The chromatin structure at a promoter can define how a gene is regulated. Studies of two yeast genes expressed in the G1 phase of the cell cycle, HO and CLN2, have provided important paradigms for transcriptional regulation. Although the SBF (Swi4/Swi6 box factor) transcription factor activat...