The present invention provides a control agent for the initial stage of the G1 phase of the cell cycle, said control agent containing: C7orf26 gene having the activity of arresting the cell cycle at the initial stage of the G1 phase and causing a transition from the G1 phase to the G0...
G1 stage the first growth phase of the eukaryoticCELL CYCLE. Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005 Want to thank TFD for its existence?Tell a friend about us, add a link to this page, or visitthe webmaster's page for free...
Since intracellular localization was detected in asynchronous culture at stationary phase (largely in post-replicative G2 stage) localization of gDDK in nuclei of trophozoites has not been reported (Lalle et al., 2012). On the contrary, re-localization of gDDK from flagellar pores to nuclei was...
The G1 Phase Cell Cycle Checkpoint refers to a stage in the cell cycle where cells in the G1 phase are prevented from entering the S phase in the presence of DNA damage, inhibiting the initiation of DNA replication. AI generated definition based on: Encyclopedia of Biological Chemistry (Secon...
Quite intriguingly, a G1/S cell cycle checkpoint deficiency occurs in a transient fashion at the initial stage of the genome reprogramming process. These cancer-like phenomena, i.e. a cell cycle checkpoint deficiency resulting in the accumulation of point mutations, suggest a common developmental ...
Interestingly, cdk4 (p<0.01) and cyclin E (p<0.05) expressions showed an inverse relationship with the tumor size and the cancer stage. A similar tendency was also detected for two other positive modulators of G1-S transition, indicating that cell cycle progression must be regulated by the ...
invasiveness of CRC. The knockdown of NDRG1 led to enhanced dissemination of CRC cells in vivo and correlates with active CDC42 expression. Using clinical sample analysis, we found an elevated level of active CDC42 in ...
andfrequentlate-stagediagnosiswithassociatedrecurrenceandmetastasis,leadingto alowproportionofcasesamenabletosurgicalintervention.CellsintheG0/G1phase arepotentialsourcesofrecurrenceandmetastasis.Duetotheirtemporaryexitfromthe cellcycle,theylacksensitivitytoconventionalradiotherapyandchemotherapy, ...
A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage. Genes Dev. 29, 1151–1163 (2015). Article PubMed PubMed Central Google Scholar Vydzhak, O., Luke, B. & Schindler, N. Non-coding RNAs at the ...
One of the most important factors determining the success of the development of cloned embryos is the cell cycle stage of the donor cells. We investigated the effects of serum starvation, culturing to confluence and roscovitine treatment on the cell cycle synchronization of goldfish caudal fin-...