G protein-coupled receptors (GPCRs) are critical cellular sensors that mediate numerous physiological processes. In the heart, multiple GPCRs are expressed on various cell types, where they coordinate to regulate cardiac function by modulating critical processes such as contractility and blood flow. Un...
Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression. Int. J. Oncol. 27, 1329–1339 (2005). CAS PubMed Google Scholar Lui, V. W. et al. Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by ...
and R. Osman, Minireview: Insights into G Protein-Coupled Receptor Function using Molecular Models. Endocrinology, 2001. 142(1): p. 2- 10.Gershengorn MC, Osman R 2001 Minireview: insights into G protein-coupled receptor function using molecular models. Endocrinology 142:2-10...
G-protein-coupled receptors (GPCRs) influence many steps in tumorigenesis, including proliferation, survival, angiogenesis, metastasis and evasion of the immune system. This Review provides an overview of the various roles of GPCRs in cancer and their po
The G-protein coupled receptors are of particular interest because all of the receptors important to psychiatry, with the exception of the ion channelglutamateandGABAAreceptors, are G-protein coupled. View chapter Review article Agonist-independent regulation of constitutively active G-protein-coup...
甘氨酸是一种抑制性神经递质,但它在发育中的神经元中的作用可能是兴奋性的[1],但尚未发现介导这些作用的受体。神经系统中的代谢神经调控通常由G蛋白偶联受体(G Protein-coupled receptors,GPCRs)通过激活异三聚体G蛋白转导信号实现[2]。G蛋白信号调节蛋白(regulator of g protein signaling protein,RGS)可促进其G蛋...
G protein-coupled receptors (GPCRs) are transmembrane proteins that participate in many physiological processes and represent major pharmacological targets. Recent advances in structural biology of GPCRs have enabled the development of drugs based on the receptor structure (structure-based drug design, SB...
近日,来自宁夏医科大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“G protein-coupled receptors (GPCRs): advances in structures,mechanisms, and drug discovery”的综述性文章,该研究揭示了G蛋白偶联受体的结构、机制和药物发现的进展。
G-protein-coupled receptors (GPCRs) influence many steps in tumorigenesis, including proliferation, survival, angiogenesis, metastasis and evasion of the immune system. This Review provides an overview of the various roles of GPCRs in cancer and their po
Ahren, B. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nature Rev. Drug. Discov. 8, 369–385 (2009). This is an excellent review on the role of GPCRs in the regulation of pancreatic β -cells and their established or potential roles as targets...