G-protein-coupled receptors (GPCRs) influence many steps in tumorigenesis, including proliferation, survival, angiogenesis, metastasis and evasion of the immune system. This Review provides an overview of the various roles of GPCRs in cancer and their po
G-protein-coupled receptors (GPCRs) influence many steps in tumorigenesis, including proliferation, survival, angiogenesis, metastasis and evasion of the immune system. This Review provides an overview of the various roles of GPCRs in cancer and their po
G protein coupled receptorsGTPasescancersignal transductionmetastasisimmune therapyprecision medicineinflammationangiogenesiscancer metabolismG protein coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their ...
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling proteins that have a pivotal role in many physiological functions and in multiple diseases, including the development of cancer and cancer metastasis. Current drugs that target GPCRs — many of which have excelle...
另一方面,癌细胞的交流系统往往存在致命漏洞,使得它们可以无视正常限制肆意生长,同时自私地掠夺资源。正常细胞转化为癌细胞时可能会有很多与交流相关的分子发生变化,这些分子中就包括GPCR(G蛋白偶联受体,G-protein-coupled receptors)。 癌症调查 最近,PSI的研究人员检查了各种各样癌细胞的DNA序列,发现GPCR信号转导系统...
G protein coupled receptors in embryonic stem cells: A role for Gs-α signaling. PLoS ONE 2010, 5, e9105. [CrossRef] [PubMed] 12. Papayannopoulou, T.; Priestley, G.V.; Bonig, H.; Nakamoto, B. The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization. ...
Keywords: breast cancer; epidermal growth factor receptor; estrogen; estrogen receptor; G-protein coupled estrogen receptor 1. Introduction Breast cancer is the most common cancer among women worldwide [1,2]. There were over two million new cases in 2018. In 2015, 14,801 new cases were ...
G protein–coupled receptors (GPCRs) are the largest gene family of cell membrane–associated molecules mediating signal transmission, and their involvement in key physiological functions is well-established. The ability of GPCRs to regulate a vast array of fundamental biological processes, such as ...
While the effects of SCFA have historically been associated with their intracellular metabolism and function, the discovery of a family of G protein-coupled free-fatty acid receptors in the early 2000's suggests that many effects of SCFA are cell-surface receptor mediated. Indeed, the SCFA GPCRs...
Many studies have been shown that environmental estrogen bisphenol A (BPA) can activate nuclear receptor (estrogen receptor alpha, ERα) or membrane receptor (G-protein-coupled receptor, GPR30) in breast cancer cells and exerts genomic or nongenomic actions inducing cell proliferation. 4,4'-thio...