2020年10月1日,佛罗里达Scripps研究所Kirill A. Martemyanov领导的研究小组在Cell杂志上发表题为A Global Map of G Protein Signaling Regulation by RGS Proteins的研究论文,在这项研究中,作者将所有经典RGS蛋白对Ga蛋白的偏好绘制成了图...
Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs). GPCRs act on inactive Gα·GDP/Gβγ heterotrimers to promote GDP release and GTP binding, resulting in liberation of Gα from Gβγ. Gα·GTP and Gβγ target effectors including adenylyl cyclases,...
Key to the regulation of the G protein signaling cascade is the involvement of cyclic AMP (cAMP). One of its key functions is to activate Guanine Exchange Factors (GEF), which in turn play a role in the activation of G proteins. Small GTPases serve to regulate a variety of cell signali...
相关研究结果于2020年10月1日在线发表在Cell期刊上,论文标题为“A Global Map of G Protein Signaling Regulation by RGS Proteins”。 图片来自CC0 Public Domain。 这些研究结果为更好地理解这类称为G蛋白信号调节蛋白(regulator of G protein signaling pro...
新鲜出炉的Cell主刊,其实属于工程学领域了,主要就是发明了一种能实时监测活体细胞内G蛋白活性的装置。 光学传感器,对不同G蛋白均有效。 参考: Signal Transduction Pathways- 以G蛋白和cAMP为例,讲得比较通俗 G-protein signaling G Protein-Coupled Receptors | Nervous system physiology | NCLEX-RN | Khan Academ...
G-proteins are important signaling molecules that transduce signals from heptahelical transmembrane receptors to downstream effectors. The localization of a G-protein to the plasma membrane is essential for its function, and prenylation plays a crucial role in this process[1]. Prenylation is a post-...
Since the initial discovery of the G protein-coupled receptor system that regulates cyclicAMP production, the G protein field has rapidly expanded. Cell surface receptors that couple to heterotrimeric G proteins, the G prote- coupled receptors (GPCRs), number in the hundreds and bind to a wide...
神经系统中的代谢神经调控通常由G蛋白偶联受体(G Protein-coupled receptors,GPCRs)通过激活异三聚体G蛋白转导信号实现[2]。G蛋白信号调节蛋白(regulator of g protein signaling protein,RGS)可促进其G蛋白信号失活[3]。GPCRs介导除甘氨酸和牛磺酸以外的所有主要神经递质的作用。然而,许多GPCR仍然没有确定的内源性...
Most of our knowledge about plant G protein signaling comes from the analysis of loss-of-function mutants and overexpression studies of the G protein subunit genes in Arabidopsis and rice, where they control a wide range of developmental and physiological processes, including cell proliferation [2,...
Reduced infiltration of anti-tumor lymphocytes remains a major cause of tumor immune evasion and is correlated with poor cancer survival. Here, we found that upregulation of regulator of G protein signaling (RGS)1 in helper TH1 cells and cytotoxic T lymphocytes (CTLs) reduced their trafficking ...