A method to study G-protein-coupled receptor (GPCR) trafficking has been developed using engineered APEX2 and CRISPR interference screening. The innovative approach reveals a network of proteins coordinated by DNAJC13 that control efficient GPCR sorting into degradative or recycling pathways. ...
其细胞质部分可以与三聚体G蛋白相互作用,其胞浆面第三个环能与鸟苷酸结合蛋白(G蛋白)偶联,通过不同的G蛋白影响腺苷酸环化酶或磷脂酶C,改变细胞内第二信使浓度,以实现跨膜信息传递。此类受体通过G蛋白向下游传递信号,因此又称为G蛋白偶联受体。结果一 题目 G蛋白偶联受体?(G protein coupled receptor) 答案 在...
G protein-coupled receptor human (GCREC) and, the invention provides polynucleotides encoding identify GCREC. The present invention also, I also provides antagonist expression vectors, host cells, antibodies, and agonists. The present invention also provides methods of diagnosing, treating or ...
[名词解释] G蛋白耦联受体(G-proteincoupledreceptor) 相关知识点: 试题来源: 解析 一种与三聚体G蛋白耦联的细胞表面受体。含有7个穿膜区,是迄今发现的最大的受体超家族,其成员有1000多个。与配体结合后通过激活所耦联的G蛋白,启动不同的信号转导通路并导致各种生物学效应。
G Protein Coupled Receptor Families Rhodopsin familySecretin/glucagon receptor familyGlutamate receptor/calcium sensor family Receptor for amine neurotransmitters, peptide, purines, prostanoids Receptor for peptide hormones, secretin, glucagon GABAB receptors, Ca2+–sensing receptors Short EC tail,...
GPCR(G Protein-Coupled Receptor),即G蛋白偶联受体,是一大类膜蛋白受体的统称。GPCR是人类基因组编码的最大蛋白家族,广泛分布于中枢神经系统、免疫系统、心血管及视网膜等器官和组织,参与机体发育以及多种生理功能的调控。 GPCR的主体由7段跨细胞质膜的α螺旋结构构成,将信号由胞外转导到胞内(图1)。基于进化同源性...
P. et al. Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature 463, 108–112 (2010). Article ADS CAS PubMed PubMed Central Google Scholar Nuber, S. et al. β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle. ...
[名词解释] G-protein linked receptor (G-蛋白偶联受体) 相关知识点: 试题来源: 解析 配体与受体结合后激活相邻的G-蛋白,被激活的G-蛋白又可激活或抑制一种产生特异第二信使的酶或离子通道,引起膜电位的变化。由于这种受体参与的信号转导作用要与GTP结合的调节蛋白相偶联,因此将它称为G蛋白偶联受体。 这类受体...
Guanine nucleotide protein- (G protein-) coupled receptors, or GPCRs, form the largest, most ubiquitous, and most variable superfamily of integral transmembrane proteins. Crystal structures of individual GPCRs allow the rational design of drugs to treat various human maladies. GPCRs are responsible ...
G-protein coupled receptorThe invention provides isolated nucleic acid and amino acid sequences of four novel G-protein coupled receptors that are amplified in breast cancer cells, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for ...