1 Yang, D. et al. G protein-coupled receptors: structure- and function-based drug discovery. Signal Transduct Target Ther 6, 7, doi:10.1038/s41392-020-00435-w (2021).2 Cong, Z. et al. Structural perspective of class B1 GPCR signaling. Trends Pharmacol Sci 43, 321-334, doi:1...
G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects or allosteric effects, and biased signaling or balanced signaling, characteri...
Guanine nucleotide protein- (G protein-) coupled receptors, or GPCRs, form the largest, most ubiquitous, and most variable superfamily of integral transmembrane proteins. Crystal structures of individual GPCRs allow the rational design of drugs to treat various human maladies. GPCRs are responsible ...
近日,来自宁夏医科大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“G protein-coupled receptors (GPCRs): advances in structures,mechanisms, and drug discovery”的综述性文章,该研究揭示了G蛋白偶联受体的结构、机制和药物发现的进展。 G蛋白偶联受体(gpcr)是最大的人膜蛋白家族,也是一...
近日,来自宁夏医科大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“G protein-coupled receptors (GPCRs): advances in structures,mechanisms, and drug discovery”的综述性文章,该研究揭示了G蛋白偶联受体的结构、机制和药物发现的进展。
G蛋白偶联受体（G protein-coupled receptors， GPCR）是最丰富的膜蛋白超家族。随着冷冻电镜技术的发展，使人们对GPCR的激活及其与胞内主要转导分子家族（G蛋白三聚体，控制细胞内信号转导）的相互作用有了新的认识。然而，目前的研究主要局限于A类、B类或F类单体形式GPCR家族，它们发挥功能是通过受体激活与结合G蛋白...
G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors and also the targets of many drugs. Understanding of the functional significance of the wide structural diversity of GPCRs has been aided considerably in recent years by the sequencing of the human genome and ...
G 蛋白偶联受体 (G-protein-coupled receptors, GPCRs) 是人类基因组中最大的蛋白质超家族。GPCRs 是一大类七次跨膜的受体蛋白，通过与 G 蛋白偶联，随后调节多种细胞内信号级联反应，以响应激素、神经递质、离子、光、气味、趋化因子和其他刺激 ，参与了众多生理过程包括感光、嗅觉、行为和情绪的调节、自主神经...
structure determinationx-rayG protein-coupled receptors (GPCRs) are integral membrane proteins that reside in the plasma membrane of eukaryotic cells. They are central to transmitting signals from the extracellular milieu to the inside of the cell. Ligand binding on the outer surface of GPCRs ...
1 Yang, D. et al. G protein-coupled receptors: structure- and function-based drug discovery. Signal Transduct Target Ther 6, 7, doi:10.1038/s41392-020-00435-w (2021). 2 Cong, Z. et al. Structural perspective of...