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Suggest new definition This definition appears somewhat frequently and is found in the following Acronym Finder categories: Military and Government See otherdefinitions of FBL Other Resources: We have 121 othermeanings of FBLin our Acronym Attic ...
These tools can be broadly categorized as motif-based or ML- and DL-based algorithms [117]. Splice Site Finder-like (SSF-like, embedded in other platforms referenced below), Genscan [106], Genesplicer [108] and MaxEntScan (MES) [107] are examples of tools employing motif-based algorithms. ...
Here we show that liver kinase B1 (LKB1) programs the metabolic and functional fitness of T reg cells in the control of immune tolerance and homeostasis. Mice with a T reg -specific deletion of LKB1 developed a fatal inflammatory disease characterized by excessive T H 2-type-dominant responses...
To determine if the two species have reciprocal benefits on each other and hence can truly be considered as a cooperative association, a more detailed analysis of their growth in co-culture will be needed. Despite the simple composition at the species level, strain-level diversity may contribute...
[59,60,61]. Stable RNA provides many benefits, including increased half-life, fine-tuning of translational speed, and establishing favorable binding sites for RNA-binding proteins and miRNAs [62,63]. mRNA conforms to structures that more easily maintain its structural integrity, which in most ...
enabling the examination of both more regions of the genome as well as more samples. The combination of these factors emphasizes the need for robust computational pipelines for analysis of mutation data. Frequency-based methods are best equipped to leverage the statistical benefits of large datasets,...
The identification of critical functional variants can be of particular importance for endangered species or bottlenecked populations to aid attempts to reduce the incidence of genetically-determined traits that decrease fitness, or limit recovery. However, the benefits of a genetic rescue approach would...
These results support the notion that the improved viral fitness of the XBB.1.5 variant may arise from the enhanced RBD stability and stronger ACE2 binding while maintaining the favorable immune escaping profile by utilizing the functional benefits of conformationally adaptive Omicron sites. These ...
Parasites are ubiquitously present across all of life [1,2]. Their negative impact on host fitness can impose strong selection on hosts to resist, tolerate, or escape potential parasites. Parasitoids are a special group of parasites whose successful reproduction is fatal to the host [3,4]. The...