Myocyte enhancer factor 2 (MEF2) transcription factors have been shown to play a critical role in the differentiation of cardiac and skeletal muscle. MEF2C is also expressed in several other cell types, including smooth muscle and endothelial cells, yet little is known about the transcriptional ...
Substances known as transcription factors often determine how a cell develops as well as which proteins it produces and in what quantities. Transcription factors bind to a section of DNA and control how strongly a gene in that section is activated. Scientists had previously assumed that gene activi...
Angiosperms contain approximately 30 genes encoding Dof transcription factors, while nonvascular plants have lower numbers of such genes. Although all Dof transcription factors exhibit similar DNA-binding properties, due to their highly conserved DNA-binding domain, they play a variety of very different ...
Functional versatility of transcription factors in the nervous system: the SRF paradigm. Trends Neurosci. 32, 432–442 (2009). PubMed Google Scholar Hardingham, G. E., Arnold, F. J. L. & Bading, H. A calcium microdomain near NMDA receptors: on-switch for ERK-dependent synapse-to-...
Arabidopsis transcription factors, MYB28, MYB29 and MYB76, positively regulate aliphatic glucosinolate (AGSL) biosynthesis. Mutual transcriptional regulation among these MYB genes makes it difficult to elucidate their individual function simply by analyzing knock-out mutants or ectopically overexpressing line...
Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription fact... Surfactant protein D (SP-D) plays critical roles in host defense, surfactant homeostasis, and pulmonary immunomodulation. Here, we identify a...
In the spontaneous nor mutant, a 2 bp deletion in the third exon of NAC-NOR causes a frameshift, resulting in a truncated protein giving a strong non-ripening phenotype19. Tomato MADS domain transcription factors FUL1 and FUL2 are co-orthologs of Arabidopsis FRUITFULL20. FUL2 is expressed...
A Gain-of-Function Screen Reveals Redundant ERF Transcription Factors Providing Opportunities for Resistance Breeding Toward the Vascular Fungal Pathogen V... A Gain-of-Function Screen Reveals Redundant ERF Transcription Factors Providing Opportunities for Resistance Breeding Toward the Vascular Fungal ...
Therefore, Foxp3 is recognized as the central regulator of Treg cells. To understand immune tolerance and immune homeostasis, how Treg cell and Foxp3 function are controlled is a critical question yet to be fully addressed. Increasing numbers of transcription factors are shown to be important for...
terminal ends.The NAC transcription factors play a role in regulation of plant growth and development,hormone level and responses to various kinds stresses.This article reviews the basic structure,biological function,expression regulation of plant NAC transcription factors and the recent research progress....